Short Communication: Fracture Risk by HIV Infection Status in Perinatally HIV-Exposed Children

被引：10

作者：

Siberry, George K. ^{[1
]}

Li, Hong ^{[2
]}

Jacobson, Denise ^{[3
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Pediat Adolescent & Maternal AIDS PAMA Branch, Ctr Res Mothers & Children, NIH, Bethesda, MD 20892 USA

[2] Rush Univ, Dept Prevent Med, Chicago, IL 60612 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Biostat, Ctr Biostat AIDS Res CBAR, Boston, MA 02115 USA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2012年 / 28卷 / 03期

关键词：

BONE-MINERAL DENSITY; NAIVE PATIENTS; THERAPY; ADOLESCENTS; TENOFOVIR; HEALTH; IMPACT; RATES;

D O I：

10.1089/aid.2011.0064

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The objective of this study was to examine the incidence of fractures in HIV-infected children and comparable HIV-exposed, uninfected (HEU) children in a multicenter, prospective cohort study (PACTG 219/219C) in the United States. The main outcome was first fracture during the risk period. Nine fractures occurred in 7 of 1326 HIV-infected and 2 of 649 HEU children, corresponding to incidence rates of 1.2 per 1000 person-years and 1.1 per 1000 person-years, respectively. The incidence rate ratio was 1.1 (95% CI 0.2, 5.5). There was no evidence of a substantially increased risk of fracture in HIV-infected compared to HEU children.

引用

页码：247 / 250

页数：4

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