Short Communication: Fracture Risk by HIV Infection Status in Perinatally HIV-Exposed Children

被引：10
作者：
Siberry, George K. [1 ]
Li, Hong [2 ]
Jacobson, Denise [3 ]
机构：
[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Pediat Adolescent & Maternal AIDS PAMA Branch, Ctr Res Mothers & Children, NIH, Bethesda, MD 20892 USA
[2] Rush Univ, Dept Prevent Med, Chicago, IL 60612 USA
[3] Harvard Univ, Sch Publ Hlth, Dept Biostat, Ctr Biostat AIDS Res CBAR, Boston, MA 02115 USA
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2012年 / 28卷 / 03期
关键词：
BONE-MINERAL DENSITY; NAIVE PATIENTS; THERAPY; ADOLESCENTS; TENOFOVIR; HEALTH; IMPACT; RATES;
D O I：
10.1089/aid.2011.0064
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The objective of this study was to examine the incidence of fractures in HIV-infected children and comparable HIV-exposed, uninfected (HEU) children in a multicenter, prospective cohort study (PACTG 219/219C) in the United States. The main outcome was first fracture during the risk period. Nine fractures occurred in 7 of 1326 HIV-infected and 2 of 649 HEU children, corresponding to incidence rates of 1.2 per 1000 person-years and 1.1 per 1000 person-years, respectively. The incidence rate ratio was 1.1 (95% CI 0.2, 5.5). There was no evidence of a substantially increased risk of fracture in HIV-infected compared to HEU children.
引用
收藏
页码：247 / 250
页数：4
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