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Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction
被引:20
作者:

Xie, Yong-Mei
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Sichuan Univ, W China Med Sch, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China Sichuan Univ, W China Med Sch, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China

Yao, Yu-Qin
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Sichuan Univ, W China Med Sch, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China Sichuan Univ, W China Med Sch, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China

Sun, Hong-Bao
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Sichuan Univ, W China Med Sch, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China Sichuan Univ, W China Med Sch, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China

Yan, Ting-Ting
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Sichuan Univ, W China Med Sch, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China Sichuan Univ, W China Med Sch, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China

Liu, Jie
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Sichuan Univ, W China Med Sch, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China Sichuan Univ, W China Med Sch, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China

Kang, Tai-Ran
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China W Normal Univ, Chem Synth & Pollut Control Key Lab Sichuan Prov, Coll Chem & Chem Engn, Nanchong 637002, Peoples R China Sichuan Univ, W China Med Sch, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China
机构:
[1] Sichuan Univ, W China Med Sch, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China
[2] China W Normal Univ, Chem Synth & Pollut Control Key Lab Sichuan Prov, Coll Chem & Chem Engn, Nanchong 637002, Peoples R China
来源:
关键词:
spiropyrrolizidine oxindoles;
cycloaddition;
isatin;
REVERSE-TRANSCRIPTASE INHIBITORS;
AZOMETHINE YLIDE CYCLOADDITION;
ALPHA-AMINO-ACIDS;
ONE-POT SYNTHESIS;
POTENTIAL 1,3-DIPOLES;
REGIOSELECTIVE SYNTHESIS;
BIOLOGICAL EVALUATIONS;
SPIROCYCLIC OXINDOLES;
SPIRO-OXINDOLES;
ZH COMPOUNDS;
D O I:
10.3390/molecules16108745
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
An efficient synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition has been achieved. This strategy can provide direct and rapid access to spiropyrrolizidine oxindoles in high yields (up to 99%) with excellent diastereoselectivities (up to 99: 1 dr). The features of this procedure are the following: mild reaction conditions, high yields, high diastereoselectivities, one-pot procedure and operational simplicity.
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页码:8745 / 8757
页数:13
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