Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction

被引:20
作者
Xie, Yong-Mei [1 ]
Yao, Yu-Qin [1 ]
Sun, Hong-Bao [1 ]
Yan, Ting-Ting [1 ]
Liu, Jie [1 ]
Kang, Tai-Ran [2 ]
机构
[1] Sichuan Univ, W China Med Sch, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China
[2] China W Normal Univ, Chem Synth & Pollut Control Key Lab Sichuan Prov, Coll Chem & Chem Engn, Nanchong 637002, Peoples R China
关键词
spiropyrrolizidine oxindoles; cycloaddition; isatin; REVERSE-TRANSCRIPTASE INHIBITORS; AZOMETHINE YLIDE CYCLOADDITION; ALPHA-AMINO-ACIDS; ONE-POT SYNTHESIS; POTENTIAL 1,3-DIPOLES; REGIOSELECTIVE SYNTHESIS; BIOLOGICAL EVALUATIONS; SPIROCYCLIC OXINDOLES; SPIRO-OXINDOLES; ZH COMPOUNDS;
D O I
10.3390/molecules16108745
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
An efficient synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition has been achieved. This strategy can provide direct and rapid access to spiropyrrolizidine oxindoles in high yields (up to 99%) with excellent diastereoselectivities (up to 99: 1 dr). The features of this procedure are the following: mild reaction conditions, high yields, high diastereoselectivities, one-pot procedure and operational simplicity.
引用
收藏
页码:8745 / 8757
页数:13
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