Protecting-group-free synthesis of carboxylic group substituted alkynes by Sonogashira coupling in water

被引：3

作者：

Zhu, Xin-Yi ^{[1
]}

Wang, Yang ^{[1
]}

Bai, Fang ^{[1
]}

Gao, Guo-Wei ^{[1
]}

Men, Jian ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Chengdu 610064, Peoples R China

来源：

ARKIVOC | 2011年

关键词：

Halogenated aromatic acids; Sonogashira coupling; phenylacetylene; water; palladium acetate; ARYL BROMIDES; CATALYZED HETEROCYCLIZATION; EFFICIENT; COMPLEX; HALIDES; LIGAND; SUZUKI;

D O I：

10.3998/ark.5550190.0012.a08

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An effective, economic and green synthesis of carboxylic group substituted alkynes by Sonogashira coupling of halogenated aromatic acids with phenylacetylene has been developed. The coupling reaction proceeds well using Pd(OAc)(2)/TPPTS-CuI as catalyst with K2CO3 as base in water. It is worth noting that this procedure avoids the protection/deprotection steps of carboxylic group and obtains the title compounds in good to excellent yields.

引用

页码：99 / +

页数：29

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