Protecting-group-free synthesis of carboxylic group substituted alkynes by Sonogashira coupling in water

被引：3
|
作者：
Zhu, Xin-Yi [1 ]
Wang, Yang [1 ]
Bai, Fang [1 ]
Gao, Guo-Wei [1 ]
Men, Jian [1 ]
机构：
[1] Sichuan Univ, Coll Chem, Chengdu 610064, Peoples R China
来源：
ARKIVOC | 2011年
关键词：
Halogenated aromatic acids; Sonogashira coupling; phenylacetylene; water; palladium acetate; ARYL BROMIDES; CATALYZED HETEROCYCLIZATION; EFFICIENT; COMPLEX; HALIDES; LIGAND; SUZUKI;
D O I：
10.3998/ark.5550190.0012.a08
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An effective, economic and green synthesis of carboxylic group substituted alkynes by Sonogashira coupling of halogenated aromatic acids with phenylacetylene has been developed. The coupling reaction proceeds well using Pd(OAc)(2)/TPPTS-CuI as catalyst with K2CO3 as base in water. It is worth noting that this procedure avoids the protection/deprotection steps of carboxylic group and obtains the title compounds in good to excellent yields.
引用
收藏
页码：99 / +
页数：29
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