Eukaryotic selenoprotein synthesis: Mechanistic insight incorporating new factors and new functions for old factors

被引：105

作者：

Squires, Jeffrey E. ^{[1
]}

Berry, Marla J. ^{[1
]}

机构：

[1] Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96813 USA

来源：

IUBMB LIFE | 2008年 / 60卷 / 04期

关键词：

selenoprotein biosynthesis; selenium; selenoprotein;

D O I：

10.1002/iub.38

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Selenium is an essential micronutrient that has been linked to various aspects of human health. Selenium exerts its biological activity through the incorporation of the amino acid, selenocysteine (See), into a unique class of proteins termed selenoproteins. See incorporation occurs cotranslationally at UGA codons in archaea, prokaryotes, and eukaryotes. UGA codons specify See coding rather than termination by the presence of specific secondary structures in mRNAs termed selenocysteine insertion (SECIS) elements, and trans-acting factors that associate with SECIS elements. Herein, we discuss the various proteins known to function in eukaryotic selenoprotein biosynthesis, including several players whose roles have only been elucidated very recently. (c) 2008 IUBMB.

引用

页码：232 / 235

页数：4

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