C2-H Arylation of Indoles Catalyzed by Palladium-Containing Metal-Organic-Framework in γ-Valerolactone

被引：27

作者：

Anastasiou, Ioannis ^{[1
]}

Van Velthoven, Niels ^{[2
]}

Tomarelli, Elena ^{[1
]}

Lombi, Aurora ^{[1
]}

Lanari, Daniela ^{[3
]}

Liu, Pei ^{[4
]}

Bals, Sara ^{[4
]}

De Vos, Dirk E. ^{[2
]}

Vaccaro, Luigi ^{[1
]}

机构：

[1] Univ Perugia, Lab Green SOC, Dipartimento Chim Biol & Biotecnol, Via Elce Sotto 8, I-06124 Perugia, Italy

[2] Katholieke Univ Leuven, Ctr Membrane Separat Adsorpt Catalysis & Spect Su, Celestijnenlaan 200F,Box 2454, B-3001 Leuven, Belgium

[3] Univ Perugia, Dipartimento Sci Farmaceut, Via Liceo 1, I-06123 Perugia, Italy

[4] Univ Antwerp, Electron Microscopy Mat Sci, Groenenborgerlaan 171, B-2020 Antwerp, Belgium

来源：

CHEMSUSCHEM | 2020年 / 13卷 / 10期

关键词：

biomass; green solvents; heterogeneous catalysis; indole; metal-organic framework; ONE-POT SYNTHESIS; BIOMASS-DERIVED SOLVENTS; DIRECT C-2 ARYLATION; H BOND ARYLATION; C-H; DIARYLIODONIUM SALTS; ROOM-TEMPERATURE; HETEROGENEOUS CATALYSTS; SELECTIVE ADSORPTION; ARYLBORONIC ACIDS;

D O I：

10.1002/cssc.202000378

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and selective procedure was developed for the direct C2-H arylation of indoles using a Pd-loaded metal-organic framework (MOF) as a heterogeneous catalyst and the nontoxic biomass-derived solvent gamma-valerolactone (GVL) as a reaction medium. The developed method allows for excellent yields and C-2 selectivity to be achieved and tolerates various substituents on the indole scaffold. The established conditions ensure the stability of the catalyst as well as recoverability, reusability, and low metal leaching into the solution.

引用

页码：2786 / 2791

页数：6

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