In vitro activities of benflumetol against 158 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs

被引：40
作者：
Pradines, B
Tall, A
Fusai, T
Spiegel, A
Hienne, R
Rogier, C
Trape, JF
Le Bras, J
Parzy, D
机构：
[1] Serv Sante Armees, Inst Trop Med, Unite Parasitol, F-13998 Marseille, France
[2] Hop Bichat Claude Bernard, Ctr Natl Reference Chimiosensibil Paludisme, F-75877 Paris, France
[3] Inst Pasteur, Serv Epidemiol, Dakar, Senegal
[4] ORSTOM, Lab Paludol, Dakar, Senegal
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 02期
关键词：
D O I：
10.1128/AAC.43.2.418
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The 50% inhibitory concentration (IC(50)s) of benflumetol (range, 12.5 to 250 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to benflumetol. Benflumetol was slightly more potent against chloroquine-resistant isolates (P < 0.025). No correlation or weak correlations in the responses to benflumetol and pyrimethamine, chloroquine, amodiaquine, artemether, quinine, and pyronaridine were observed, and these correlations are insufficient to suggest cross-resistance. Benflumetol may be an important alternative drug for the treatment of chloroquine-resistant malaria.
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页码：418 / 420
页数：3
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