Matrix Metalloproteinases in Helicobacter pylori-Associated Gastritis and Gastric Cancer

被引：25

作者：

Sokolova, Olga ^{[1
]}

Naumann, Michael ^{[1
]}

机构：

[1] Otto von Guericke Univ, Inst Expt Internal Med, Fac Med, Leipziger Str 44, D-39120 Magdeburg, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 03期

关键词：

inflammation; NF-kappa B; MAP kinases; type IV secretion system; EPITHELIAL-MESENCHYMAL TRANSITION; SINGLE NUCLEOTIDE POLYMORPHISM; NF-KAPPA-B; GENE-EXPRESSION; CELL INVASION; PROGNOSTIC-FACTOR; MATRILYSIN MMP-7; IMMUNE-RESPONSE; IN-VITRO; C-MET;

D O I：

10.3390/ijms23031883

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastric cancer is one of the leading causes of the cancer-related mortality worldwide. The etiology of this disease is complex and involves genetic predisposition and environmental factors, including Helicobacter pylori. Infection of the stomach with H. pylori leads to gastritis and gastric atrophy, which can progress stepwise to gastric cancer. Matrix metalloproteinases (MMPs) actively participate in the pathology development. The further progression of gastric cancer seems to be less dependent on bacteria but of intra-tumor cell dynamics. Bioinformatics data confirmed an important role of the extracellular matrix constituents and specific MMPs in stomach carcinoma invasion and metastasis, and revised their potential as predictors of the disease outcome. In this review, we describe, in detail, the impact of MMPs in H. pylori-associated gastritis and gastric cancer.

引用

页数：17

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