Cytotoxic trichilin-type limonoids from Melia azedarach

被引：37
|
作者：
Takeya, K [1 ]
Qiao, ZS [1 ]
Hirobe, C [1 ]
Itokawa, H [1 ]
机构：
[1] TOKYO UNIV PHARM & LIFE SCI,DEPT NAT MED,HACHIOJI,TOKYO 19203,JAPAN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 1996年 / 4卷 / 08期
关键词：
D O I：
10.1016/0968-0896(96)00128-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Five new trichilin-type limonoids, named 12-deacetyltrichilin I (1), 1-acetyltrichilin H (2), 3-deacetyltrichilin H (3), 1-acetyl-3-deacetyltrichilin H (4), 1-acetyl-2-deacetyltrichilin H (5), together with four known trichilins, meliatoxin B-1 (6), trichilin H (7), trichilin D (8) and 1,12-diacetyltrichilin B (9) were isolated from the extract of the root bark of Melia azedarach. The structures were elucidated by spectroscopic means and their cytotoxic activities against P388 cells in vitro were tested by means of MTT assay. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：1355 / 1359
页数：5
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