Glycine N-Methyltransferase Affects Urinary 1-Hydroxypyrene and 8-Hydroxy-2′-Deoxyguanosine Levels After PAH Exposure

被引：10

作者：

Chen, Marcelo ^{[2
,3
,10
]}

Ho, Chiao-Wei ^{[2
]}

Huang, Yu-Chuen ^{[4
,5
]}

Wu, Kuen-Yuh ^{[6
]}

Wu, Ming-Tseng ^{[7
,8
,12
]}

Jeng, Hueiwang Anna ^{[9
]}

Chen, Chiou-Jong ^{[10
]}

Shih, Tung-Sheng ^{[10
]}

Lai, Ching-Huang ^{[11
]}

Pan, Chih-Hong ^{[10
,11
]}

Chen, Yi-Ming Arthur ^{[1
,10
]}

机构：

[1] Natl Yang Ming Univ, Sch Med, Inst Microbiol & Immunol, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Inst Publ Hlth, Div Prevent Med, Taipei 112, Taiwan

[3] Mackay Mem Hosp, Dept Urol, Taipei, Taiwan

[4] China Med Univ Hosp, Dept Med Res, Genet Ctr, Taichung, Taiwan

[5] China Med Univ, Coll Chinese Med, Sch Chinese Med, Taichung, Taiwan

[6] Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Taipei 10764, Taiwan

[7] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Grad Inst Occupat Safety & Hlth, Kaohsiung, Taiwan

[8] Kaohsiung Municipal Hsiaokang Hosp, Ctr Environm & Occupat Med, Kaohsiung, Taiwan

[9] Old Dominion Univ, Coll Hlth Sci, Sch Community & Environm Hlth, Norfolk, VA 23529 USA

[10] Council Labor Affairs, Inst Occupat Safety & Hlth, Taipei, Taiwan

[11] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan

[12] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung, Taiwan

来源：

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 2011年 / 53卷 / 07期

关键词：

POLYCYCLIC AROMATIC-HYDROCARBONS; TUMOR SUSCEPTIBILITY GENE; OXIDATIVE DNA-DAMAGE; 8-HYDROXYDEOXYGUANOSINE; EXCRETION; WORKERS; CANCER; EXPRESSION; 8-HYDROXY-2-DEOXYGUANOSINE; INTERVENTION;

D O I：

10.1097/JOM.0b013e318222b79a

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objectives: The object of this study was to assess the modulating effects of genetic polymorphisms of glycine N-methyltransferase (GNMT) genotypes on 1-hydroxypyrene (1-OHP) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in urine from coke-oven workers, consistently exposed to polycyclic aromatic hydrocarbons (PAHs). Methods: The study participants included 289 coke-oven workers from a steel company in Taiwan. Personal air samples, spot urine samples, peripheral blood samples, and questionnaires were used to quantify PAH exposure, oxidative DNA damage, GNMT gene polymorphisms, demographic data, and environmental pollutants. Results: Urinary 1-OHP level, GNMT STRP1 genotype, and worksite were significant predictors of urinary 8-OHdG levels after adjustments were made for covariates. Conclusions: This study suggests that GNMT STRP1 could modulate urinary 1-OHP and 8-OHdG levels in coke-oven workers exposed to PAHs.

引用

页码：812 / 819

页数：8

共 38 条

[1] CANCER OF THE STOMACH AND THE COLON-RECTUM AMONG WORKERS IN A COKE GAS PLANT
BERGER, J
MANZ, A
[J]. AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, 1992, 22 (06) : 825 - 834
[2] Coke oven workers study:: the effect of exposure and GSTM1 and NAT2 genotypes on DNA adduct levels in white blood cells and lymphocytes as determined by 32P-postlabelling
Binková, B
Topinka, J
Mracková, G
Gajdosová, D
Vidová, P
Stávková, Z
Peterka, V
Pilcîk, T
Rimár, V
Dobiás, L
Farmer, PB
Srám, RJ
[J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 1998, 416 (1-2) : 67 - 84
[3] Caux Chantal, 2002, Appl Occup Environ Hyg, V17, P379, DOI 10.1080/10473220252864987
[4] Repeated Measurements of Urinary Methylated/Oxidative DNA Lesions, Acute Toxicity, and Mutagenicity in Coke Oven Workers
Chao, Mu-Rong
Wang, Chien-Jen
Wu, Ming-Tsang
Pan, Chih-Hong
Kuo, Chung-Yih
Yang, Hao-Jan
Chang, Louis W.
Hu, Chiung-Wen
[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2008, 17 (12) : 3381 - 3389
[5] CHAU N, 1993, BRIT J IND MED, V50, P127
[6] Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway
Chen, SY
Lin, JRV
Darbha, R
Lin, PP
Liu, TY
Chen, YMA
[J]. CANCER RESEARCH, 2004, 64 (10) : 3617 - 3623
[7] Further evidence for a possible role of conformation in the immunogenicity and antigenicity of the oxidative DMA lesion, 8-oxo-2′deoxyguanosine
Cooke, MS
Herbert, KE
Butler, PC
Lunec, J
[J]. FREE RADICAL RESEARCH, 1998, 28 (05) : 459 - 469
[8] DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine
Cooke, MS
Evans, MD
Dove, R
Rozalski, R
Gackowski, D
Siomek, A
Lunec, J
Olinski, R
[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2005, 574 (1-2) : 58 - 66
[9] Folic acid deficiency and cancer: mechanisms of DNA instability
Duthie, SJ
[J]. BRITISH MEDICAL BULLETIN, 1999, 55 (03) : 578 - 592
[10] Biomarker evidence of DNA oxidation in lung cancer patients: Association of urinary 8-hydroxy-2'-deoxyguanosine excretion with radiotherapy, chemotherapy, and response to treatment
Erhola, M
Toyokuni, S
Okada, K
Tanaka, T
Hiai, H
Ochi, H
Uchida, K
Osawa, T
Nieminen, MM
Alho, H
KellokumpuLehtinen, P
[J]. FEBS LETTERS, 1997, 409 (02) : 287 - 291

← 1 2 3 4 →