Characterization of a highly virulent and antimicrobial-resistant Acinetobacter baumannii strain isolated from diseased chicks in China

被引：13

作者：

Liu, Dong ^{[1
]}

Liu, Zeng-Shan ^{[1
]}

Hu, Pan ^{[1
]}

Hui, Qi ^{[1
]}

Fu, Bao-Quan ^{[2
]}

Lu, Shi-Ying ^{[1
]}

Li, Yan-Song ^{[1
]}

Zou, De-Ying ^{[1
,3
]}

Li, Zhao-Hui ^{[1
]}

Yan, Dong-Ming ^{[1
]}

Ding, Yan-Xia ^{[1
]}

Zhang, Yuan-Yuan ^{[1
]}

Zhou, Yu ^{[1
]}

Liu, Nan-Nan ^{[1
]}

Ren, Hong-Lin ^{[1
]}

机构：

[1] Jilin Univ, Coll Vet Med, Inst Zoonosis, Key Lab Zoonosis Res,Minist Educ, Xi An Da Lu 5333, Changchun 130062, Peoples R China

[2] Chinese Acad Agr Sci, State Key Lab Vet Etiol Biol, Key Lab Vet Parasitol Gansu Prov, Key Lab Vet Publ Hlth,Minist Agr,Lanzhou Vet Res, Lanzhou 730046, Peoples R China

[3] Panjin Inspect & Testing Ctr, Panjin 124010, Peoples R China

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2016年 / 60卷 / 08期

关键词：

Acinetobacter baumannii; antibiotic resistance; chick; LD50; SUSCEPTIBILITY; INFECTIONS; SYSTEM;

D O I：

10.1111/1348-0421.12400

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Poultry husbandry is a very important aspect of the agricultural economy in China. However, chicks are often susceptible to infectious disease microorganisms, such as bacteria, viruses and parasites, causing large economic losses in recent years. In the present study, we isolated an Acinetobacter baumannii strain, CCGGD201101, from diseased chicks in the Jilin Province of China. Regression analyses of virulence and LD50 tests conducted using healthy chicks confirmed that A. baumannii CCGGD201101, with an LD50 of 1.81 (+/- 0.11) x 10(4) CFU, was more virulent than A. baumannii ATCC17978, with an LD50 of 1.73 (+/- 0.13) x 10(7) CFU. Moreover, TEM examination showed that the pili of A. baumannii CCGGD201101 were different from those of ATCC17978. Antibiotic sensitivity analyses showed that A. baumannii CCGGD201101 was sensitive to rifampicin but resistant to most other antibiotics. These results imply that A. baumannii strain CCGGD201101 had both virulence enhancement and antibiotic resistance characteristics, which are beneficial for A. baumannii survival under adverse conditions and enhance fitness and invasiveness in the host. A. baumannii CCGGD20101, with its high virulence and antimicrobial resistance, may be one of the pathogens causing death of diseased chicks.

引用

页码：533 / 539

页数：7

共 31 条

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