Subjective cognitive decline: preclinical manifestation of Alzheimer's disease

被引：68
作者：
Lin, Yan [1 ]
Shan, Pei-Yan [2 ]
Jiang, Wen-Jing [2 ]
Sheng, Can [3 ]
Ma, Lin [2 ]
机构：
[1] Shandong Univ, Dept Neurol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China
[2] Shandong Univ, Dept Gerontol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China
[3] Tsinghua Univ, Hosp 1, Dept Neurol, Beijing 100016, Peoples R China
来源：
NEUROLOGICAL SCIENCES | 2019年 / 40卷 / 01期
基金：
美国国家科学基金会;
关键词：
Subjective cognitive decline; Alzheimer's disease; Preclinical; Biomarkers; Neuroimaging; CEREBROSPINAL-FLUID BIOMARKERS; MEDIAL TEMPORAL-LOBE; OLDER-ADULTS; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; MEMORY COMPLAINTS; IMPAIRMENT; INDIVIDUALS; HIPPOCAMPAL;
D O I：
10.1007/s10072-018-3620-y
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Subjective cognitive decline (SCD), characterized by a very early and subtle cognitive decline prior to the appearance of objective cognitive impairment, is considered to be the preclinical manifestation of Alzheimer's disease (AD). Given the lack of significant abnormalities in standardized neuropsychological assessments for individuals with SCD, biochemical and neuroimaging biomarkers may be important indicators of the preclinical stage of AD. The application of various biomarkers derived from the cerebrospinal fluid and neuroimaging thus has the potential to make AD-related pathology detectable in vivo. In this review, we discuss the conceptual evolution of SCD as an entity and further elucidate characteristic cerebrospinal fluid and neuroimaging biomarkers of SCD.
引用
收藏
页码：41 / 49
页数：9
相关论文
共 64 条
[1]  
Abner E L, 2015, J Prev Alzheimers Dis, V2, P11
[2]   The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].
Albert, Marilyn S. ;
DeKosky, Steven T. ;
Dickson, Dennis ;
Dubois, Bruno ;
Feldman, Howard H. ;
Fox, Nick C. ;
Gamst, Anthony ;
Holtzman, David M. ;
Jagust, William J. ;
Petersen, Ronald C. ;
Snyder, Peter J. ;
Carrillo, Maria C. ;
Thies, Bill ;
Phelps, Creighton H. .
ALZHEIMERS & DEMENTIA, 2011, 7 (03) :270-279
[3]  
Ali JI, 2018, J ALZHEIMERS DIS, V65, P303, DOI [10.3233/JAD-180248, 10.3233/jad-180248]
[4]   Different profiles of Alzheimer's disease cerebrospinal fluid biomarkers in controls and subjects with subjective memory complaints [J].
Antonell, Anna ;
Fortea, Juan ;
Rami, Lorena ;
Bosch, Beatriz ;
Balasa, Mircea ;
Sanchez-Valle, Raquel ;
Iranzo, Alex ;
Luis Molinuevo, Jose ;
Llado, Albert .
JOURNAL OF NEURAL TRANSMISSION, 2011, 118 (02) :259-262
[5]   Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden [J].
Buckley, Rachel F. ;
Hanseeuw, Bernard ;
Schultz, Aaron P. ;
Vannini, Patrizia ;
Aghjayan, Sarah L. ;
Properzi, Michael J. ;
Jackson, Jonathan D. ;
Mormino, Elizabeth C. ;
Rentz, Dorene M. ;
Sperling, Reisa A. ;
Johnson, Keith A. ;
Amariglio, Rebecca E. .
JAMA NEUROLOGY, 2017, 74 (12) :1455-1463
[6]   Targeting the Prodromal Stage of Alzheimer's Disease: Bioenergetic and Mitochondrial Opportunities [J].
Caldwell, Charles C. ;
Yao, Jia ;
Brinton, Roberta Diaz .
NEUROTHERAPEUTICS, 2015, 12 (01) :66-80
[7]   From mild cognitive impairment to subjective cognitive decline: conceptual and methodological evolution [J].
Cheng, Yu-Wen ;
Chen, Ta-Fu ;
Chiu, Ming-Jang .
NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2017, 13 :491-498
[8]   Hippocampal Atrophy Is Associated with Subjective Memory Decline: The PATH Through Life Study [J].
Cherbuin, Nicolas ;
Sargent-Cox, Kerry ;
Easteal, Simon ;
Sachdev, Perminder ;
Anstey, Kaarin J. .
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2015, 23 (05) :446-455
[9]   Larger temporal volume in elderly with high versus low beta-amyloid deposition [J].
Chetelat, Gael ;
Villemagne, Victor L. ;
Pike, Kerryn E. ;
Baron, Jean-Claude ;
Bourgeat, Pierrick ;
Jones, Gareth ;
Faux, Noel G. ;
Ellis, Kathryn A. ;
Salvado, Olivier ;
Szoeke, Cassandra ;
Martins, Ralph N. ;
Ames, David ;
Masters, Colin L. ;
Rowe, Christopher C. .
BRAIN, 2010, 133 :3349-3358
[10]   Amyloid and Tau Biomarkers in Subjective Cognitive Impairment [J].
Colijn, Mark A. ;
Grossberg, George T. .
JOURNAL OF ALZHEIMERS DISEASE, 2015, 47 (01) :1-8
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