HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic

被引：2
作者：
Schinkelshoek, Mink [1 ,2 ]
Fronczek, Rolf [1 ,2 ]
Verduijn, Willem [3 ]
Haasnoot, Geert [3 ]
Overeem, Sebastiaan [4 ,5 ]
Donjacour, Claire [6 ]
van der Heide, Astrid [7 ]
Roelen, Dave [3 ]
Claas, Frans [3 ]
Lammers, Gert Jan [1 ,2 ]
机构：
[1] Leiden Univ, Dept Neurol, Med Ctr, POB 9600, NL-2300 RC Leiden, Netherlands
[2] SEIN, Sleep Wake Ctr, Achterweg 5, NL-2103 SW Heemstede, Netherlands
[3] Leiden Univ, Dept Immunohematol & Blood Transfus, Med Ctr, POB 9600, NL-2300 RC Leiden, Netherlands
[4] Sleep Med Ctr Kempenhaeghe, POB 61, NL-5590 AB Heeze, Netherlands
[5] Eindhoven Univ Technol, Dept Elect Engn, POB 513, NL-5600 MB Eindhoven, Netherlands
[6] SEIN, Sleep Wake Ctr, Dokter Denekampweg 20, NL-8025 BV Zwolle, Netherlands
[7] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol & Neurosurg, Univ Weg 100, NL-3584 CG Utrecht, Netherlands
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 342卷
关键词：
Narcolepsy; H1N1; HLA; Hypocretin; Auto-immune disease; CONFER RISK; VACCINATION; INFLUENZA; PROTECTION; CATAPLEXY;
D O I：
10.1016/j.jneuroim.2020.577210
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We aimed to compare HLA-DQB1-associations in narcolepsy type 1 (NT1) patients with disease onset before and after the 2009 H1N1 pandemic in a large Dutch cohort 525 NT1 patients and 1272 HLA-DQB1*06:02-positive healthy controls were included. Because of the discussion that has arisen on the existence of sporadic and post-H1N1 NT1, HLA-DQB1-associations in pre- and post-H1N1 NT1 patients were compared. The associations between HLA-DQB1 alleles and NT1 were not significantly different between pre- and post-H1N1 NT1 patients. Both HLA-DQB1-associations with pre- and -post H1N1 NT1 reported in recent smaller studies were replicated. Our findings combine the results of studies in pre- and post-H1N1 NT1 and argue against considering post-H1N1 NT1 as a different entity.
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页数：5
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