Association of serum osteocalcin levels with major adverse cardiovascular events: A 4.4-year retrospective cohort study

We investigated whether the serum osteocalcin levels at baseline were associated with the incidence of major adverse cardiovascular events (MACE) in a population-based retrospective cohort study of Chinese subjects. Coronary angiography was used to diagnose coronary artery disease (CAD). Survival curves were analyzed by performing log-rank tests with Kaplan-Meier figures. Multivariable Cox proportional hazards regression was performed to identify the association of serum osteocalcin levels with the incidence of MACE. A total of 247 subjects with a mean age of 65.50 +/- 10.38years were enrolled in the analysis. After a mean follow-up time of 4.4 +/- 2.6years, MACE occurred in 175 cases. For men patients, those with serum osteocalcin levels higher than 17.22ng/mL had significantly lower fasting plasma glucose (FPG) than those with serum osteocalcin levels lower than 17.22ng/mL (P<.05). According to the multivariate Cox proportional hazards regression, the lower serum osteocalcin levels and the higher risk of future MACE occurred in men with CAD at baseline (hazard ratio=0.970; 95% confidence interval 0.943-0.999, P=.04). However, this difference was not significant either in men without CAD or in women. In conclusion, relatively lower serum osteocalcin levels were associated with a higher risk of MACE in Chinese men with CAD.