Poiretia latifolia essential oil as a promising antifungal and anti-inflammatory agent: Chemical composition, biological screening, and development of a nanoemulsion formulation

被引：15
作者：
Nunes Alves Paim, Luis Fernando [1 ]
Dalla Lana, Daiane Flores [2 ]
Giaretta, Mosiele [2 ]
Danielli, Leticia Jacobi [2 ]
Fuentefria, Alexandre Meneghello [1 ,2 ]
Apel, Miriam Anders [2 ]
Kulkamp-Guerreiro, Irene Clemes [1 ,2 ]
机构：
[1] Univ Fed Rio Grande do Sul, Programa Posgrad Farmacol & Terapeut, Porto Alegre, RS, Brazil
[2] Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Farmaceut, Porto Alegre, RS, Brazil
来源：
INDUSTRIAL CROPS AND PRODUCTS | 2018年 / 126卷
关键词：
Poiretia latifolia; Fabaceae; Carvone; Limonene; Nanoemulsion; Biological screening; ANTIMICROBIAL ACTIVITY; MENTHA-SPICATA; ANTIOXIDANT; LIMONENE; RESISTANCE; CARVONE;
D O I：
10.1016/j.indcrop.2018.10.016
中图分类号：
S2 [农业工程];
学科分类号：
0828 ;
摘要：
Poiretia latifolia is a Brazilian plant species used in traditional medicine for a wide range of ailments. The objective of this study was to evaluate the antioxidant potential, anti-inflammatory activity, and antifungal effect of P. latifolia essential oil and its major compounds. In addition, a nanoemulsifled system was developed for its application. Aerial parts of the plant, collected at different stages of development, were hydrodistilled, and the chemical composition of the oil was determined by gas chromatography-mass spectrometry (GC-MS). Limonene, trans-dihydrocarvone, and carvone were identified as major compounds. Antioxidant potential was evaluated by three different methods: TBARS, beta-carotene/linoleic acid, and DPPH center dot. P. latifolia oil showed antioxidant activity (0.508 mg/mL) in lipophilic medium, as evidenced by the beta-carotene/linoleic acid assay. The anti-chemotactic effect of the oil was evaluated by inhibition of neutrophil migration (0.001-10 mu g/mL): P. latifolia oil was able to inhibit up to 94.7% of migration. Antifungal activity was evaluated against yeasts (Candida spp.) and dermatophytic filamentous fungi (Microsporutn spp. and Trichophyton spp.). P. latifolia oil showed antifungal activity against Microsporum cards, and a mixture of carvone and limonene was effective against the dermatophytes Trichophyton rubrum and Trichophyton mentagrophytes. Nanoemulsions were successfully developed. P. latifolia oil has the potential to be used as an antidermatophytic and anti-inflammatory agent.
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收藏
页码：280 / 286
页数：7
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