Anxiety and Depression in Patients with Chronic Obstructive Pulmonary Disease in China: Results from the China Pulmonary Health [CPH] Study

被引：17

作者：

Huang, Ke ^{[1
,2
]}

Huang, Kewu ^{[3
]}

Xu, Jianying ^{[4
]}

Yang, Lan ^{[5
]}

Zhao, Jianping ^{[6
]}

Zhang, Xiangyan ^{[7
]}

Bai, Chunxue ^{[8
]}

Kang, Jian ^{[9
]}

Ran, Pixin ^{[10
]}

Shen, Huahao ^{[11
]}

Wen, Fuqiang ^{[12
,13
]}

Chen, Yahong ^{[14
]}

Sun, Tieying ^{[15
]}

Shan, Guangliang ^{[16
]}

Lin, Yingxiang ^{[3
]}

Wu, Sinan ^{[2
,17
]}

Yang, Ting ^{[1
,2
,18
]}

Wang, Chen ^{[1
,2
,18
,19
]}

机构：

[1] China Japan Friendship Hosp, Dept Pulm & Crit Care Med, Ctr Resp Med, Beijing 100029, Peoples R China

[2] Natl Clin Res Ctr Resp Dis, Dept Pulm & Crit Care Med, Beijing, Peoples R China

[3] Capital Med Univ, Beijing Chao Yang Hosp, Dept Pulm & Crit Care Med, Beijing Key Lab Resp & Pulm Circulat Disorders, Beijing, Peoples R China

[4] Shanxi Dayi Hosp, Dept Pulm & Crit Care Med, Taiyuan, Peoples R China

[5] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, Xian, Peoples R China

[6] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pulm & Crit Care Med, Wuhan, Peoples R China

[7] Guizhou Prov Peoples Hosp, Dept Pulm & Crit Care Med, Guiyang, Peoples R China

[8] Fudan Univ, Zhongshan Hosp, Dept Pulm & Crit Care Med, Shanghai, Peoples R China

[9] China Med Univ, Hosp 1, Dept Pulm & Crit Care Med, Shenyang, Peoples R China

[10] Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Dis, State Key Lab Resp Dis,Natl Clin Res Ctr Resp Dis, Guangzhou, Peoples R China

[11] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Resp & Crit Care Med, Hangzhou, Peoples R China

[12] Sichuan Univ, West China Hosp, State Key Lab Biotherapy China, Chengdu, Peoples R China

[13] Sichuan Univ, West China Hosp, Dept Resp & Crit Care Med, Chengdu, Peoples R China

[14] Peking Univ Third Hosp, Dept Resp & Crit Care Med, Beijing, Peoples R China

[15] Beijing Hosp, Dept Resp & Crit Care Med, Beijing, Peoples R China

[16] Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med, Inst Basic Med Sci, Beijing, Peoples R China

[17] China Japan Friendship Hosp, Inst Clin Med Sci, Ctr Resp Med, Beijing, Peoples R China

[18] Capital Med Univ, Dept Resp Med, Beijing, Peoples R China

[19] Chinese Acad Med Sci, Inst Resp Med, Beijing, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 2021年 / 16卷

基金：

国家重点研发计划;

关键词：

anxiety; COPD; depression; Hospital Anxiety and Depression Scale; HADS; HOSPITAL ANXIETY; COPD PATIENTS; PREVALENCE; DISORDERS; METAANALYSIS; MANAGEMENT; SYMPTOMS; IMPACT; RISK;

D O I：

10.2147/COPD.S328617

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Purpose: Anxiety and depression are often underdiagnosed and affect the prognosis of patients with chronic obstructive pulmonary disease (COPD). We analyzed data from the China Pulmonary Health (CPH) study to assess the prevalence of anxiety and depression in COPD patients and their relationship with disease severity. Patients and Methods: A total of 57,779 subjects aged 20 years or older were recruited in the CPH study. All participants were assessed using a standard questionnaire and underwent pulmonary function tests before and after the use of a bronchodilator in local health centers. The Hospital Anxiety and Depression Scale (HADS) questionnaire with a cutoff score of 8 was used to define anxiety and depression. The prevalence of anxiety and depression in patients of COPD were investigated. Multivariate logistic regression was used to investigate the effects of COPD and lung function on anxiety and depression. Results: A total of 49,053 participants (20,661 men and 28,392 women) completed the questionnaire with reliable post-bronchodilator pulmonary function test results and were included in the final analysis, of which 4686 (9.55%) were diagnosed with COPD. Of the patients with COPD, 10.79% had anxiety, 13.65% had depression, and 7.08% had anxiety and depression concomitantly. In the multivariate logistic regression analysis, COPD was not significantly associated with anxiety, depression, or both. After adjusting for confounders in model 1, patients in the GOLD III-IV group had a significantly higher risk of anxiety, depression, and their coincidence. After further adjusting for respiratory symptoms in model 2, lung function impairment in the GOLD III-IV group was only significantly associated with a higher risk of depression or at least one of anxiety and depression. Conclusion: Anxiety and depression are prevalent in patients with COPD in China. More severe lung function impairment is significantly associated with a higher risk of depression.

引用

页码：3387 / 3396

页数：10

共 32 条

[21] Risk of depression in patients with chronic obstructive pulmonary disease and its determinants [J].

van Manen, JG ;

Bindels, PJE ;

Dekker, FW ;

IJzermans, CJ ;

van der Zee, JS ;

Schadé, E .

THORAX, 2002, 57 (05) :412-416

[22] The association of anxiety and depression with mortality in a COPD cohort. The HUNT study, Norway [J].

Vikjord, Sigrid Anna Aalberg ;

Brumpton, Ben Michael ;

Mai, Xiao-Mei ;

Vanfleteren, Lowie ;

Langhammer, Arnulf .

RESPIRATORY MEDICINE, 2020, 171

[23] Are patients with COPD psychologically distressed? [J].

Wagena, EJ ;

Arrindell, WA ;

Wouters, EFM ;

van Schayck, CP .

EUROPEAN RESPIRATORY JOURNAL, 2005, 26 (02) :242-248

[24]

Wang C, 2018, LANCET, V391, P1706, DOI [10.1016/S0140-6736(18)30841-9, 10.1016/s0140-6736(18)30841-9]

[25] Anxiety Disorders in Patients With COPD: A Systematic Review [J].

Willgoss, Thomas George ;

Yohannes, Abebaw Mengistu .

RESPIRATORY CARE, 2013, 58 (05) :858-866

[26] Depressive disorders in older patients with chronic obstructive pulmonary disease (COPD) in Hong Kong: a controlled study [J].

Wong, Tak-Shun ;

Xiang, Yu-Tao ;

Tsoh, Joshua ;

Ungvari, Gabor S. ;

Ko, Fanny W. S. ;

Hui, David S. C. ;

Chiu, Helen F. K. .

AGING & MENTAL HEALTH, 2014, 18 (05) :588-592

[27] Prevalence and risk factors of small airway dysfunction, and association with smoking, in China: findings from a national cross-sectional study [J].

Xiao, Dan ;

Chen, Zhengming ;

Wu, Sinan ;

Huang, Kewu ;

Xu, Jianying ;

Yang, Lan ;

Xu, Yongjian ;

Zhang, Xiangyan ;

Bai, Chunxue ;

Kang, Jian ;

Ran, Pixin ;

Shen, Huahao ;

Wen, Fuqiang ;

Yao, Wanzhen ;

Sun, Tieying ;

Shan, Guangliang ;

Yang, Ting ;

Lin, Yingxiang ;

Zhu, Jianguo ;

Wang, Ruiying ;

Shi, Zhihong ;

Zhao, Jianping ;

Ye, Xianwei ;

Song, Yuanlin ;

Wang, Qiuyue ;

Hou, Gang ;

Zhou, Yumin ;

Li, Wen ;

Ding, Liren ;

Wang, Hao ;

Chen, Yahong ;

Guo, Yanfei ;

Xiao, Fei ;

Lu, Yong ;

Peng, Xiaoxia ;

Zhang, Biao ;

Wang, Zuomin ;

Zhang, Hong ;

Bu, Xiaoning ;

Zhang, Xiaolei ;

An, Li ;

Zhang, Shu ;

Cao, Zhixin ;

Zhan, Qingyuan ;

Yang, Yuanhua ;

Liang, Lirong ;

Liu, Zhao ;

Zhang, Xinran ;

Cheng, Anqi ;

Cao, Bin .

LANCET RESPIRATORY MEDICINE, 2020, 8 (11) :1081-1093

[28] Independent Effect of Depression and Anxiety on Chronic Obstructive Pulmonary Disease Exacerbations and Hospitalizations [J].

Xu, Wanning ;

Collet, Jean-Paul ;

Shapiro, Stanley ;

Lin, Yingxiang ;

Yang, Ting ;

Platt, Robert W. ;

Wang, Chen ;

Bourbeau, Jean .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 178 (09) :913-920

[29] Depression and anxiety in patients with COPD [J].

Yohannes, Abebaw M. ;

Alexopoulos, George S. .

EUROPEAN RESPIRATORY REVIEW, 2014, 23 (133) :345-349

[30] Prevalence of depressive symptoms in patients with chronic obstructive pulmonary disease: a systematic review, meta-analysis and meta-regression [J].

Zhang, Melvyn W. B. ;

Ho, Roger C. M. ;

Cheung, Mike W. L. ;

Fu, Erin ;

Mak, Anselm .

GENERAL HOSPITAL PSYCHIATRY, 2011, 33 (03) :217-223

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