Application of Flow Cytometry in Pediatric Hematology-Oncology

被引：8

作者：

Varma, Neelam ^{[1
]}

Naseem, Shano ^{[2
]}

机构：

[1] Postgrad Inst Med Educ & Res, Dept Hematol, Chandigarh 160012, India

[2] Postgrad Inst Med Educ & Res, Div Pediat Hematol, Adv Pediat Ctr, Chandigarh 160012, India

来源：

PEDIATRIC BLOOD & CANCER | 2011年 / 57卷 / 01期

关键词：

acute lymphoblastic leukemia; acute myeloid leukemia; flow cytometry; oncology; pediatric; ACUTE LYMPHOBLASTIC-LEUKEMIA; MINIMAL RESIDUAL DISEASE; HEMATOPOIETIC STEM; PERIPHERAL-BLOOD; BONE-MARROW; CLINICAL-SIGNIFICANCE; GENE REARRANGEMENTS; MRD DETECTION; DNA-PLOIDY; CELLS;

D O I：

10.1002/pbc.22954

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Applications of flow cytometry in pediatric cancers have expanded substantially in recent years. In acute leukemias, the commonest childhood cancer, flow cytometry can now define complex antigenic profiles that are associated with specific cytogenetic/molecular defects and can also directly identify BCR-ABL fusion protein. Flow cytometry based scoring system has been described for diagnosis of myelodysplastic syndromes. In solid tumors, flow cytometry was previously used mainly to determine DNA content for prognosis; however, recent studies in children with neuroblastoma and Ewing sarcoma have identified its diagnostic utility. In this review, we will discuss the current and future applications of flow cytometry in pediatric hematology-oncology. Pediatr Blood Cancer 2011;57:18-29. (C) 2011 Wiley-Liss, Inc.

引用

页码：18 / 29

页数：12

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