A Bioprinted Liver-on-a-Chip for Drug Screening Applications

被引：104

作者：

Knowlton, Stephanie ^{[1
]}

Tasoglu, Savas ^{[1
,2
]}

机构：

[1] Univ Connecticut, Dept Biomed Engn, 260 Glenbrook Rd, Storrs, CT 06269 USA

[2] Univ Connecticut, Dept Mech Engn, 191 Auditorium Rd, Storrs, CT 06269 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2016年 / 34卷 / 09期

关键词：

Microfluidics - Scaffolds (biology) - Cell engineering - Tissue - Three dimensional computer graphics;

D O I：

10.1016/j.tibtech.2016.05.014

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The need for a liver-on-a-chip tissue model for drug screening is particularly important in tissue engineering because of the high frequency of drug-induced liver injury. Recently, a liver tissue model conducive to hepatotoxicity testing was developed by bioprinting hepatic spheroids encapsulated in a hydrogel scaffold into a microfluidic device. © 2016 Elsevier Ltd

引用

页码：681 / 682

页数：2

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