TNF signaling in vascular endothelial cells

被引：272

作者：

Madge, LA ^{[1
]}

Pober, JS

机构：

[1] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Interdept Program Vascular Biol & Transplantat, New Haven, CT 06520 USA

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2001年 / 70卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1006/exmp.2001.2368

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Vascular endothelium is a major target of actions of the proinflammatory cytokine tumor necrosis factor (TNF). Increasingly, the intracellular pathways that are activated in response to TNF have been elucidated. Many of these pathways have proven to be cell type-specific, requiring that observations made in other cell types be confirmed or ruled out in endothelial cells (EC). In this review the authors will summarize the state of the field, emphasizing studies in cultured human EC. (C) 2001 Academic Press.

引用

页码：317 / 325

页数：9

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