A mixture of poly-γ-glutamic acid and levan ameliorates obesity in high fat diet-induced mice

Anti-obesity effects of a mixture of poly-gamma-glutamic acid (gamma-PGA) and levan (PL, 6:4 w/w) were evaluated using C57BL/6 mouse models including normal diet (G1), normal diet containing 5% of PL (G2), high-fat diet (HFD) (G3), HFD with 3% of PL (G4), and HFD with 5% of PL (G5) and followed by breeding 12 weeks. After 12 weeks, the content of epididymal fat and the size of fat cell for test animals were significantly decreased by comparing G3 (p < 0.05). Similarily, contents of serum triglyceride, total cholesterol, LDL cholesterol, insulin and leptin in G5 were significantly decreased than G3. Fat accumulations and inflammatory degrees within liver and fat cells were also decreased in the G5 than G3. In addition 5% PL diet might not have any problems causing liver damages. Conclusively, a mixture of gamma-PGA and levan could help to improve obesity and dyslipidemia due to high-fat meals.