Combined 1H and 31P spectroscopy provides new insights into the pathobiochemistry of brain damage in multiple sclerosis

被引:57
作者
Hattingen, Elke [1 ]
Magerkurth, Joerg [1 ]
Pilatus, Ulrich [1 ]
Huebers, Annemarie [2 ]
Wahl, Mathias [2 ]
Ziemann, Ulf [2 ]
机构
[1] Goethe Univ Frankfurt, Inst Neuroradiol, D-60528 Frankfurt, Germany
[2] Goethe Univ Frankfurt, Dept Neurol, D-60528 Frankfurt, Germany
关键词
MRS; phosphorus; creatine; choline; multiple sclerosis; 3; T; MAGNETIC-RESONANCE-SPECTROSCOPY; APPEARING WHITE-MATTER; PROTON MR SPECTROSCOPY; IN-VIVO P-31; 4; TESLA; METABOLITE CONCENTRATIONS; CHOLINE; SPECTRA; LESIONS; QUANTIFICATION;
D O I
10.1002/nbm.1621
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
H-1 MRSI has evolved as an important tool to study the onset and progression of brain damage in multiple sclerosis. Abnormal increases in total creatine, total choline and myoinositol have been noted in multiple sclerosis. However, the pathobiochemical mechanisms related to these changes are still largely unclear. The combination of H-1 MRSI and H-1-decoupled P-31 MRSI can specify to what extent phosphorylated components of total creatine and total choline contribute to this increase. Combined H-1 and P-31 MRSI data were obtained at 3 T in 22 patients with multiple sclerosis and in 23 healthy controls, and aligned with structural MRI to allow for correction for partial volume effects caused by cerebrospinal fluid and lesion load. A significant increase in total creatine was found in multiple sclerosis, and this was attributed to equal changes in the phosphorylated and unphosphorylated components. The concentrations of the putative glial markers total creatine and myoinositol in lesion-free H-1 MRSI voxels correlated with the global lesion load. We conclude that changes in total creatine are not related to altered energy metabolism, but rather indicate gliosis. Together with the increase in myoinositol, total creatine can be considered as a biomarker for disease severity. A significant total choline increase was mainly a result of choline components not visible by P-31 MRS. The origin of this residual choline fraction remains to be investigated. Copyright (C) 2010 John Wiley & Sons, Ltd.
引用
收藏
页码:536 / 546
页数:11
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