Hypotensive effect of UDP on intraocular pressure in rabbits

被引：28

作者：

Markovskaya, Anna ^{[1
]}

Crooke, Almudena ^{[2
]}

Guzman-Aranguez, Ana I. ^{[2
]}

Peral, Assumpta ^{[3
]}

Ziganshin, Airat U. ^{[1
]}

Pintor, Jesus ^{[2
]}

机构：

[1] Kazan VI Lenin State Univ, Dept Pharmacol, Kazan 420008, Russia

[2] UCM, EU Opt, Dept Bioquim, Madrid 28037, Spain

[3] Univ Complutense Madrid, EU Opt, Dept Opt Optometria & Vis 2, E-28037 Madrid, Spain

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2008年 / 579卷 / 1-3期

关键词：

glaucoma; intraocular pressure; IOP; P2Y(6) receptors; UDP;

D O I：

10.1016/j.ejphar.2007.10.040

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nucleotides can modify intraocular pressure (IOP). We have tested the ability of uridine-5'-diphosphate, UDP, for modulating IOP in New Zealand white rabbits. Uridine 5' diphosphate, UDP, reduced IOP by 82.9 +/- 2.6% compared to control. Dose-response analysis demonstrated a concentration dependent pattern which presented a pD(2) value of 7.57 +/- 1.45, equivalent to an EC50 of 26.91 nM. Of all the tested P2 receptor antagonists, suramin, pyridoxalphosphate-6-azophenyl-2, 4-disulfonic acid (PPADS) and Reactive Blue 2 (RB-2), only the last two were able to reverse the action triggered by UDP. Altogether, UDP acting probably on P2Y(6) receptors present on the ciliary processes, can reduce intraocular pressure, indicating that this substance may be used for the treatment of ocular hypertension and glaucoma. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：93 / 97

页数：5

共 25 条

[1]

Abrams LS, 1996, INVEST OPHTH VIS SCI, V37, P940

[2] Cellular distribution and functions of P2 receptor subtypes in different systems [J].

Burnstock, G ;

Knight, GE .

INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL. 240, 2004, 240 :31-+

[3]

CLARK AF, 1999, EMERG DRUGS, V4, P333

[4] Identification of a novel human ADP receptor coupled to Gi [J].

Communi, D ;

Gonzalez, NS ;

Detheux, M ;

Brézillon, S ;

Lannoy, V ;

Parmentier, M ;

Boeynaems, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (44) :41479-41485

[5] Evidence for multiple P2Y receptors in trabecular meshwork cells [J].

Crosson, CE ;

Yates, PW ;

Bhat, AN ;

Mukhin, YV ;

Husain, S .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 309 (02) :484-489

[6]

Crosson CE, 1996, INVEST OPHTH VIS SCI, V37, P1833

[7]

CROSSON CE, 1995, J PHARMACOL EXP THER, V273, P320

[8]

Davson H., 1993, PHYSL EYE, P34

[9] Swelling-activated chloride channels in aqueous humour formation: on the one side and the other [J].

Do, C. W. ;

Civan, M. M. .

ACTA PHYSIOLOGICA, 2006, 187 (1-2) :345-352

[10] Extracellular ATP: A growth factor for vascular smooth muscle cells [J].

Erlinge, D .

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1998, 31 (01) :1-8

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