Synthesis of 3-(hydroxymethyl)-3-indol-3′-yloxindoles via Rh(II)-catalyzed three-component reaction of 3-diazooxindoles, indoles and formalin

被引：14

作者：

Jing, Changcheng ^{[1
]}

Xing, Dong ^{[1
]}

Wang, Chengjin ^{[1
]}

Hu, Wenhao ^{[1
]}

机构：

[1] E China Normal Univ, Sch Chem & Mol Engn, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai 200062, Peoples R China

来源：

TETRAHEDRON | 2015年 / 71卷 / 22期

关键词：

Mixed 3,3 '-bisindole; Carbene; Multi-component reaction; Zwitterion; Aldol addition; CATALYZED CARBENE INSERTION; ENANTIOSELECTIVE TOTAL-SYNTHESIS; CROSS-COUPLING REACTION; C-H FUNCTIONALIZATION; DIAZO-COMPOUNDS; CYCLIZATION REACTIONS; EFFICIENT SYNTHESIS; N-TOSYLHYDRAZONES; VINYL HALIDES; CONSTRUCTION;

D O I：

10.1016/j.tet.2015.02.053

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient rhodium(II)-catalyzed three-component reaction of 3-diazooxindoles, indoles and formalin was reported. With this transformation, a series of 3-(hydroxymethyl)-3-indo1-3'-yloxindoles were easily afforded in good to excellent yields. The resulted 3-(hydroxymethyl)-3-indol-3'-yloxindole could be easily converted to the key intermediate for the total synthesis of gliocladin C. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：3597 / 3602

页数：6

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