Effects of Antrodia camphorata on Alcohol Clearance and Antifibrosis in Livers of Rats Continuously Fed Alcohol

被引：35

作者：

Wu, Min-Tze ^{[1
]}

Tzang, Bor-Show ^{[2
,3
,4
]}

Chang, Yuan-Yen ^{[4
,5
]}

Chiu, Chih-Hsien ^{[7
]}

Kang, Wen-Yu ^{[6
]}

Huang, Chia-Hsin ^{[1
]}

Chen, Yi-Chen ^{[7
]}

机构：

[1] Agr Res Inst Taiwan, Biotechnol Div, Council Agr, Taichung 413, Taiwan

[2] Chung Shan Med Univ, Inst Biochem & Biotechnol, Taichung 402, Taiwan

[3] Chung Shan Med Univ, Sch Med, Dept Biochem, Taichung 402, Taiwan

[4] Chung Shan Med Univ Hosp, Clin Lab, Taichung 402, Taiwan

[5] Chung Shan Med Univ, Sch Med, Dept Microbiol & Immunol, Taichung 402, Taiwan

[6] Chung Shan Med Univ, Sch Nutr, Taichung 402, Taiwan

[7] Natl Taiwan Univ, Dept Anim Sci & Technol, Taipei 106, Taiwan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2011年 / 59卷 / 08期

关键词：

alcoholic fatty liver; Antrodia camphorata; liver lipid accumulation; liver damage index; alcohol metabolism; fibrosis; GANODERMA-LUCIDUM; SUBMERGED CULTURE; FRUITING BODY; FIBROSIS; ACTIVATION; SILYMARIN; DISEASE; CELLS;

D O I：

10.1021/jf104561h

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Alcoholic fatty liver disease (AFLD) is the result of an excessive or chronic consumption of alcohol. Nine male Wistar rats per group were randomly assigned to one of the following drinking treatments: a 20% (w/w) alcohol solution (ALC); a 20% (w/w) alcohol solution cotreated with 0.25 g silymarin/kg BW/day; or a 20% (w/w) alcohol solution cotreated with 0.025 g Niuchangchih (Antrodia camphorata)/kg BW/day for 4 weeks. Rats with cotreatrnents of silymarin or Niuchangchih had smaller (p < 0.05) relative liver size, less (p < 0.05) liver lipid accumulation, and lower (p < 0.05) liver damage indices [aspartate aminotransferase (AST) and alkaline phosphatase (ALP) values]. In the regulation of alcohol metabolism, the lower serum alcohol level was observed only in alcohol-fed rats supplemented with Niuchangchih. Meanwhile, cotreatment of silymarin or Niuchangchih increased (p < 0.05) CAT and ALDH activities but did not (p > 0.05) affect ADH and CYP2E1 expressions, which accelerate alcohol metabolism in the body. Additionally, neither silymarin nor Niuchangchih (p > 0.05) influenced serum/hepatic MMP-2 activities and NF-kappa B, AP1, and alpha-SMA gene expressions, but serum/hepatic MMP-9 activities and TNF-alpha, KLF-6, and TGF-beta 1 gene expressions of alcohol-fed rats were down-regulated (p < 0.05) by silymarin or Niuchangchih, which also could explain the lower, liver damage observed in rats chronically fed alcohol.

引用

页码：4248 / 4254

页数：7

共 28 条

[1] Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases [J].

Ao, Zong-Hua ;

Xu, Zheng-Hong ;

Lu, Zhen-Ming ;

Xu, Hong-Yu ;

Zhang, Xiao-Mei ;

Dou, Wen-Fang .

JOURNAL OF ETHNOPHARMACOLOGY, 2009, 121 (02) :194-212

[2] Preventive Effects of Taurine on Development of Hepatic Steatosis Induced by a High-Fat/Cholesterol Dietary Habit [J].

Chang, Yuan-Yen ;

Chou, Chung-Hsi ;

Chiu, Chih-Hsien ;

Yang, Kuo-Tai ;

Lin, Yi-Ling ;

Weng, Wei-Lien ;

Chen, Yi-Chen .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (01) :450-457

[3] Deficiency of inducible nitric oxide synthase exacerbates hepatic fibrosis in mice fed high-fat diet [J].

Chen, Y ;

Hozawa, S ;

Sawamura, S ;

Sato, S ;

Fukuyama, N ;

Tsuji, C ;

Mine, T ;

Okada, Y ;

Tanino, R ;

Ogushi, Y ;

Nakazawa, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 326 (01) :45-51

[4] Matrix metalloproteinases and their inhibitors as markers of inflammation and fibrosis in chronic liver disease [J].

Consolo, M. ;

Amoroso, A. ;

Spandidos, D. A. ;

Mazzarino, M. C. .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2009, 24 (02) :143-152

[5] Dehydration of concentrated ganoderma lucidum extraction by combined microwave-vacuum and conventional vacuum drying [J].

Cui, ZW ;

Xu, SY ;

Sun, DW ;

Chen, W .

DRYING TECHNOLOGY, 2006, 24 (05) :595-599

[6] The role of KLF6 and its splice variants in cancer therapy [J].

DiFeo, Analisa ;

Martignetti, John A. ;

Narla, Goutham .

DRUG RESISTANCE UPDATES, 2009, 12 (1-2) :1-7

[7]

Donohue TM, 2007, WORLD J GASTROENTERO, V13, P4974

[8]

Farinati F., 1989, ALCOHOL CLIN EXP RES, V3, P357

[9]

Fernandes JC, 2002, BIORHEOLOGY, V39, P237

[10] Antioxidative and hepatoprotective effects of Antrodia camphorata extract [J].

Hsiao, G ;

Shen, MY ;

Lin, KH ;

Lan, MH ;

Wu, LY ;

Chou, DS ;

Lin, CH ;

Su, CH ;

Sheu, JR .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (11) :3302-3308

← 1 2 3 →