C1q+macrophages: passengers or drivers of cancer progression

被引：103

作者：

Revel, Margot ^{[1
]}

Sautes-Fridman, Catherine ^{[1
]}

Fridman, Wolf-Herman ^{[1
]}

Roumenina, Lubka T. ^{[1
]}

机构：

[1] Univ Paris, Sorbonne Univ, INSERM, Ctr Rech Cordeliers, F-75006 Paris, France

来源：

TRENDS IN CANCER | 2022年 / 8卷 / 07期

关键词：

COMPLEMENT PROTEIN C1Q; MACROPHAGES; LANDSCAPE; POLARIZATION; CELLS;

D O I：

10.1016/j.trecan.2022.02.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The omics era made possible the quest for efficient markers for cancer progression and revealed that macrophage populations are much more complex than just the M1/M2 dichotomy. Complement C1q pops up as a marker of a tolerogenic and immunosuppressive macrophage populations in both healthy and tumor tissues, but the specific role of C1q+ tumor-associated macrophages (TAM) is poorly understood. C1q is co-expressed in healthy and tumor macrophages with human leukocyte antigen DR (HLA-DR), Apolipoprotein E (APOE), and mannose receptor C-type 1 (MRC1) (CD206), suggesting a resident origin of this population. TAM expressing C1q correlate with T cell exhaustion and poor prognosis in numerous cancers. Herein, we discuss the plural roles of C1q in these macrophages and how it could drive cancer progression.

引用

页码：517 / 526

页数：10

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