Synthesis and evaluation of a broad range of new chiral phosphine-carbene ligands for asymmetric hydrogenation

被引：9

作者：

Passays, Johan ^{[1
,2
,3
]}

Ayad, Tahar ^{[4
]}

Ratovelomanana-Vidal, Virginie ^{[4
]}

Gaumont, Annie-Claude ^{[5
,6
]}

Jubault, Philippe ^{[1
,2
,3
]}

Leclerc, Eric ^{[1
,2
,3
]}

机构：

[1] INSA Rouen, F-76821 Mont St Aignan, France

[2] Univ Rouen, CNRS, UMR 6014, COBRA, F-76821 Mont St Aignan, France

[3] Univ Rouen, FR 3038, IRCOF, F-76821 Mont St Aignan, France

[4] Chim Paristech, Lab Charles Friedel, Ecole Natl Super Chim Paris, CNRS,UMR 7223, F-75231 Paris 05, France

[5] ENSICAEN, Lab Chim Mol & Thioorgan, CNRS, UMR 6507,INC3M,FR 3038, F-14050 Caen, France

[6] Univ Caen, F-14050 Caen, France

来源：

TETRAHEDRON-ASYMMETRY | 2011年 / 22卷 / 05期

关键词：

N-HETEROCYCLIC CARBENES; SUBSTITUTED BETA-AMIDOPHOSPHINES; PALLADIUM COMPLEXES; ENANTIOSELECTIVE HYDROGENATION; OLEFIN METATHESIS; IMIDAZOLIUM SALTS; NHC LIGANDS; CATALYSTS; CHEMISTRY; HYDROSILYLATION;

D O I：

10.1016/j.tetasy.2011.02.017

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A straightforward and gram scale synthesis (six-step synthesis from enantioenriched beta-hydroxy esters) of new structurally simple phosphine-carbene ligands bearing a single stereogenic centre has been achieved. Enantioselectivities of up to 60-63% could be achieved in the hydrogenation of methylstilbene and dehydroaminoacids when the reactions were performed under 20-50 bar hydrogen pressure. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：562 / 574

页数：13

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