Evaluation of the role of angiogenic factors in the pathogenesis of schistosomiasis

被引：25
作者：
Shariati, F. [1 ]
Perez-Arellano, J. L. [2 ]
Carranza, C. [2 ]
Lopez-Aban, J. [1 ]
Vicente, B. [1 ]
Arefi, M. [3 ]
Muro, A. [1 ]
机构：
[1] Univ Salamanca, Fac Farm, Lab Inmunol & Parasitol Mol, CIETUS, E-37007 Salamanca, Spain
[2] Univ Las Palmas Gran Canaria, Dept Ciencias Med & Quirurg, Fac Ciencias Salud, Las Palmas Gran Canaria 35080, Spain
[3] Hosp Clin Univ Salamanca, Serv Hematol, Salamanca, Spain
来源：
EXPERIMENTAL PARASITOLOGY | 2011年 / 128卷 / 01期
关键词：
Schistosoma mansoni; Schistosomiasis; Angiogenesis; VEGF; FGF2; Endostatin; AFRICAN IMMIGRANTS; EGG ANTIGENS; MANSONI; DISEASES; GROWTH; EOSINOPHILIA; ENDOSTATIN; INFECTION; THERAPY; MICE;
D O I：
10.1016/j.exppara.2011.01.016
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Schistosomiasis is one disease produced by helminths, which affect many people in tropical areas. Granuloma formation is the main mechanism involved in the pathogenesis of this disease. Experimental studies have demonstrated angiogenesis (blood vessels formation from pre-existing vessels) in the initial phase of granuloma formation. In the present work, VEGF (vascular endothelial growth factor) levels were analyzed in sera from people diagnosed with different helminthic infections. Patients with schistosomiasis and filariasis had significantly high VEGF levels in compared with healthy people and patients diagnosed with hookworms. In addition, the effects of angiogenesis inhibition using anti-angiogenic factors (endostatin) were evaluated in a schistosomiasis murine model. A lesion decrease was observed in mice infected with Schistosoma mansoni and treated with endostatin. Finally, mechanisms of angiogenesis induction were studied and observed that cercariae antigens stimulated the angiogenic factors by host alveolar macrophages. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：44 / 49
页数：6
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