Effects of hot water extract of Curcuma longa on human epidermal keratinocytes in vitro and skin conditions in healthy participants: A randomized, double-blind, placebo-controlled trial

被引:18
作者
Asada, Kazuki [1 ]
Ohara, Tatsuya [1 ]
Muroyama, Koutarou [1 ]
Yamamoto, Yoshihiro [1 ]
Murosaki, Shinji [1 ]
机构
[1] House Wellness Foods Corp, Inst Res & Dev, Itami, Hyogo, Japan
关键词
bisacurone; Curcuma longa; hyaluronan; inflammation; skin; MOLECULAR-CLONING; HYALURONAN SYNTHESIS; MONOCYTE ADHESION; ACID; PSORIASIS; EXPRESSION; HYDRATION; CERAMIDE;
D O I
10.1111/jocd.12890
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Curcuma longa has been reported to have anti-inflammatory effects. Skin inflammation impairs skin functions. Objectives: Our aim was to investigate the effect of a hot water extract of C longa (WEC) on skin conditions in cell studies using keratinocytes and in clinical trials. Methods: We measured proinflammatory cytokine levels in ultraviolet B-irradiated keratinocytes in the presence or absence of WEC. The effects of WEC on hyaluronan production in keratinocytes were also determined. In a randomized, double-blind, placebo-controlled trial, 47 healthy participants were assigned to 8-week intervention groups with daily intakes of WEC with or without curcumin or a placebo. The water content and transepidermal water loss in the face and minimal erythema dose on the back after ultraviolet B irradiation were evaluated every 4 weeks. Results: Hot water extract of C longa significantly inhibited increases in ultraviolet B-induced tumor necrosis factor alpha and interleukin 1 beta at the mRNA and protein levels. WEC also significantly increased hyaluronan production from nonstimulated keratinocytes. In the randomized, double-blind, placebo-controlled trial, increases from baseline in the water content of the face were significantly greater at weeks 4 and 8 in the WEC group, but not in the WEC + curcumin group, than in the placebo group. There were no significant differences in transepidermal water loss and minimal erythema dose among the groups. Conclusions: The cell studies confirmed that WEC has anti-inflammatory effects and augments hyaluronan production in the skin. The results of clinical trials suggest that WEC may be useful for moisturizing facial skin. Trial registration: UMIN Clinical Trials Registry 000028510. Retrospectively registered.
引用
收藏
页码:1866 / 1874
页数:9
相关论文
共 40 条
  • [1] 김민선, 2013, [Journal of the Korean Society of Food Science and Nutrition, 한국식품영양과학회지], V42, P570
  • [2] Human skin pigmentation: melanocytes modulate skin color in response to stress
    Costin, Gertrude-E.
    Hearing, Vincent J.
    [J]. FASEB JOURNAL, 2007, 21 (04) : 976 - 994
  • [3] Dahiya Parveen, 2013, N Am J Med Sci, V5, P309, DOI 10.4103/1947-2714.112473
  • [4] Di Nardo A, 1998, ACTA DERM-VENEREOL, V78, P27
  • [5] Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-α-tocopherol (vitamin E)
    Eberlein-König, B
    Placzek, M
    Przybilla, B
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1998, 38 (01) : 45 - 48
  • [6] Effect of Curcumin on Hepatic Antioxidant Enzymes Activities and Gene Expressions in Rats Intoxicated with Aflatoxin B1
    El-Bahr, S. M.
    [J]. PHYTOTHERAPY RESEARCH, 2015, 29 (01) : 134 - 140
  • [7] Relative contribution of NF-κB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytes
    Grandjean-Laquerriere, A
    Gangloff, SC
    Le Naour, R
    Trentesaux, C
    Hornebeck, W
    Guenounou, M
    [J]. CYTOKINE, 2002, 18 (03) : 168 - 177
  • [8] Multitargeting by turmeric, the golden spice: From kitchen to clinic
    Gupta, Subash C.
    Sung, Bokyung
    Kim, Ji Hye
    Prasad, Sahdeo
    Li, Shiyou
    Aggarwal, Bharat B.
    [J]. MOLECULAR NUTRITION & FOOD RESEARCH, 2013, 57 (09) : 1510 - 1528
  • [9] Mechanism of UVB-Induced Wrinkling of the Skin: Paracrine Cytokine Linkage between Keratinocytes and Fibroblasts Leading to the Stimulation of Elastase
    Imokawa, Genji
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 2009, 14 (01) : 36 - 43
  • [10] Mammalian hyaluronan synthases
    Itano, N
    Kimata, K
    [J]. IUBMB LIFE, 2002, 54 (04) : 195 - 199