Genome-Wide Testing of Exonic Variants and Breast Cancer Risk in the California Teachers Study

被引：0

作者：

Lacson, John Charles A. ^{[1
]}

Ma, Huiyan ^{[2
]}

Lee, Eunjung ^{[1
]}

Neuhausen, Susan L. ^{[2
]}

Anton-Culver, Hoda ^{[3
]}

Reynolds, Peggy ^{[4
,5
]}

Nelson, David O. ^{[4
]}

Ziogas, Argyrios ^{[3
]}

Van Den Berg, David ^{[1
]}

Deapen, Dennis M. ^{[1
]}

Bernstein, Leslie ^{[2
]}

Schumacher, Fredrick R. ^{[6
]}

机构：

[1] Univ Southern Calif, Dept Prevent Med, Keck Sch Medicine, Los Angeles, CA USA

[2] City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA

[3] Univ Calif Irvine, Sch Med, Dept Epidemiol, Irvine, CA 92717 USA

[4] Canc Prevent Inst Calif, Berkeley, CA USA

[5] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA USA

[6] Case Western Reserve Univ, Dept Epidemiol & Biostat, 10900 Euclid Ave, Cleveland, OH 44106 USA

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2017年 / 26卷 / 09期

关键词：

ASSOCIATION; RARE; SUSCEPTIBILITY;

D O I：

10.1158/1055-9965.EPI-17-0364

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Few studies have focused on the relationship of exonic variation with breast cancer and subtypes defined by tumor markers: estrogen receptor (ER), progesterone receptor (PR), and HER2. Methods: Wegenotyped 1,764 breast cancer patients and 1,400 controls from the California Teachers Study cohort using the Infinium HumanExome Beadchip. Individual variant and genebased analyses were conducted for overall breast cancer and by individual tumor marker subtype. Results: No exonic variants or gene-based analyses were statistically significantly associated with breast cancer overall or by ER-, PR-, or HER2-defined subtype. Conclusions: We did not detect any novel statistically significant exonic variants with overall breast cancer risk or by subtype. Impact: Exonic variants in the exome chip may not be associated with overall breast cancer or subtype susceptibility. (C) 2017 AACR.

引用

页码：1462 / 1465

页数：4

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