Long Noncoding Competing Endogenous RNA Networks in Pancreatic Cancer

被引：11

作者：

Xiong, Guangbing ^{[1
]}

Pan, Shutao ^{[1
]}

Jin, Jikuan ^{[1
]}

Wang, Xiaoxiang ^{[1
]}

He, Ruizhi ^{[1
]}

Peng, Feng ^{[1
]}

Li, Xu ^{[1
]}

Wang, Min ^{[1
]}

Zheng, Jianwei ^{[1
]}

Zhu, Feng ^{[1
]}

Qin, Renyi ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Biliary Pancreat Surg, Wuhan, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

基金：

中国国家自然科学基金;

关键词：

pancreatic cancer; long noncoding RNA; microRNA; competing endogenous RNA; network; EPITHELIAL-MESENCHYMAL TRANSITION; SQUAMOUS-CELL CARCINOMA; ANRIL INHIBITS PROLIFERATION; DUCTAL ADENOCARCINOMA; HEPATOCELLULAR-CARCINOMA; TUMOR-GROWTH; GEMCITABINE RESISTANCE; PROMOTES PROLIFERATION; MOLECULAR-MECHANISMS; SIGNALING PATHWAY;

D O I：

10.3389/fonc.2021.765216

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer (PC) is a highly malignant disease characterized by insidious onset, rapid progress, and poor therapeutic effects. The molecular mechanisms associated with PC initiation and progression are largely insufficient, hampering the exploitation of novel diagnostic biomarkers and development of efficient therapeutic strategies. Emerging evidence recently reveals that noncoding RNAs (ncRNAs), including long ncRNAs (lncRNAs) and microRNAs (miRNAs), extensively participate in PC pathogenesis. Specifically, lncRNAs can function as competing endogenous RNAs (ceRNAs), competitively sequestering miRNAs, therefore modulating the expression levels of their downstream target genes. Such complex lncRNA/miRNA/mRNA networks, namely, ceRNA networks, play crucial roles in the biological processes of PC by regulating cell growth and survival, epithelial-mesenchymal transition and metastasis, cancer stem cell maintenance, metabolism, autophagy, chemoresistance, and angiogenesis. In this review, the emerging knowledge on the lncRNA-associated ceRNA networks involved in PC initiation and progression will be summarized, and the potentials of the competitive crosstalk as diagnostic, prognostic, and therapeutic targets will be comprehensively discussed.

引用

页数：24

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