UniProt: a hub for protein information

被引：3623

作者：

Bateman, Alex ^{[1
]}

Martin, Maria Jesus ^{[1
]}

O'Donovan, Claire ^{[1
]}

Magrane, Michele ^{[1
]}

Apweiler, Rolf ^{[1
]}

Alpi, Emanuele ^{[1
]}

Antunes, Ricardo ^{[1
]}

Arganiska, Joanna ^{[1
]}

Bely, Benoit ^{[1
]}

Bingley, Mark ^{[1
]}

Bonilla, Carlos ^{[1
]}

Britto, Ramona ^{[1
]}

Bursteinas, Borisas ^{[1
]}

Chavali, Gayatri ^{[1
]}

Cibrian-Uhalte, Elena ^{[1
]}

Da Silva, Alan ^{[1
]}

De Giorgi, Maurizio ^{[1
]}

Dogan, Tunca ^{[1
]}

Fazzini, Francesco ^{[1
]}

Gane, Paul ^{[1
]}

Cas-tro, Leyla Garcia ^{[1
]}

Garmiri, Penelope ^{[1
]}

Hatton-Ellis, Emma ^{[1
]}

Hieta, Reija ^{[1
]}

Huntley, Rachael ^{[1
]}

Legge, Duncan ^{[1
]}

Liu, Wudong ^{[1
]}

Luo, Jie ^{[1
]}

MacDougall, Alistair ^{[1
]}

Mutowo, Prudence ^{[1
]}

Nightin-gale, Andrew ^{[1
]}

Orchard, Sandra ^{[1
]}

Pichler, Klemens ^{[1
]}

Poggioli, Diego ^{[1
]}

Pundir, Sangya ^{[1
]}

Pureza, Luis ^{[1
]}

Qi, Guoying ^{[1
]}

Rosanoff, Steven ^{[1
]}

Saidi, Rabie ^{[1
]}

Sawford, Tony ^{[1
]}

Shypitsyna, Aleksandra ^{[1
]}

Turner, Edward ^{[1
]}

Volynkin, Vladimir ^{[1
]}

Wardell, Tony ^{[1
]}

Watkins, Xavier ^{[1
]}

Zellner, Hermann ^{[1
]}

Cowley, Andrew ^{[1
]}

Figueira, Luis ^{[1
]}

Li, Weizhong ^{[1
]}

McWilliam, Hamish ^{[1
]}

机构：

[1] European Bioinformat Inst, European Mol Biol Lab, Cambridge CB10 1SD, England

[2] SIB Swiss Inst Bioinformat, Ctr Med Univ, CH-1211 Geneva 4, Switzerland

[3] Georgetown Univ, Med Ctr, Prot Informat Resource, Washington, DC 20007 USA

[4] Univ Delaware, Prot Informat Resource, Newark, DE 19711 USA

来源：

NUCLEIC ACIDS RESEARCH | 2015年 / 43卷 / D1期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

DATABASE; ANNOTATION;

D O I：

10.1093/nar/gku989

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

UniProt is an important collection of protein sequences and their annotations, which has doubled in size to 80 million sequences during the past year. This growth in sequences has prompted an extension of UniProt accession number space from 6 to 10 characters. An increasing fraction of new sequences are identical to a sequence that already exists in the database with the majority of sequences coming from genome sequencing projects. We have created a new proteome identifier that uniquely identifies a particular assembly of a species and strain or subspecies to help users track the provenance of sequences. We present a new website that has been designed using a user-experience design process. We have introduced an annotation score for all entries in UniProt to represent the relative amount of knowledge known about each protein. These scores will be helpful in identifying which proteins are the best characterized and most informative for comparative analysis. All UniProt data is provided freely and is available on the web at http://www.uniprot.org/.

引用

页码：D204 / D212

页数：9

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