Amidochromenes for Promising Antileishmanial Activity

被引：0

作者：

Neghra, Abdelhak ^{[1
]}

Lecso, Marylin ^{[2
]}

Butel, Marie-Jose ^{[2
]}

Espindola, Laila S. ^{[3
]}

Deguin, Brigitte ^{[1
]}

Seguin, Elisabeth ^{[4
]}

机构：

[1] Univ Paris 05, Sorbonne Paris Cite, CNRS, Fac Pharm Paris,UMR 8638,Lab Pharmacognosie, 4 Ave Observ, F-75006 Paris, France

[2] Univ Paris 05, Sorbonne Paris Cite, Fac Pharm Paris, Lab Microbiol,EA 4065, 4 Ave Observ, F-75006 Paris, France

[3] Univ Brasilia, Lab Farmacognosia, Campus Univ Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil

[4] Normandie Univ, UNIROUEN, INSA Rouen, CNRS,COBRA,UMR 6014, F-76000 Rouen, France

来源：

NATURAL PRODUCT COMMUNICATIONS | 2017年 / 12卷 / 09期

关键词：

Amidochromenes; Leischmaniasis; Antifungal activity; Antibacterial activity; LEISHMANIASIS; DISCOVERY;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Numerous natural products having a 2,2-dimethylchromene (2,2-dimethylbenzopyrane) structural element present interesting biological activities that may, therefore, be considered as privileged pharmacophore. Nine aliphatic and aromatic amides were synthesized from the 5-amino-7-methoxy-2,2-dimethyl-2H-chromene synthon. The antibacterial, antifungal, antileishmanial and cytotoxic activities of all amidochromenes were evaluated. No antibacterial or antifungal activity was observed. Nevertheless, three aromatic amides compounds shown significant antileishmanial activity with an excellent selectivity index.

引用

页码：1459 / 1462

页数：4

共 18 条

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