Hydrogel-clay Nanocomposites as Carriers for Controlled Release

被引:19
|
作者
Ianchis, Raluca [1 ]
Ninciuleanu, Claudia Mihaela [1 ]
Gifu, Ioana Catalina [1 ]
Alexandrescu, Elvira [1 ]
Nistor, Cristina Lavinia [1 ]
Nitu, Sabina [1 ]
Petcu, Cristian [1 ]
机构
[1] ICECHIM Bucharest, Natl Inst Res & Dev Chem & Petrochem, Spl Independentei 202,6th Dist, Bucharest 0600021, Romania
关键词
Clay; drug; hydrogel; nanocomposites; controlled release; hydrogel-clay; biopolymer; CONTROLLED DRUG-RELEASE; IMPROVED RESPONSE RATE; METHYLENE-BLUE DYE; SOL-GEL TRANSITION; IN-VITRO RELEASE; COMPOSITE HYDROGELS; SWELLING BEHAVIOR; MECHANICAL-PROPERTIES; HALLOYSITE NANOTUBES; HYBRID HYDROGELS;
D O I
10.2174/0929867325666180831151055
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The present review aims to summarize the research efforts undertaken in the last few years in the development and testing of hydrogel-clay nanocomposites proposed as carriers for controlled release of diverse drugs. Their advantages, disadvantages and different compositions of polymers/biopolymers with diverse types of clays, as well as their interactions are discussed. Illustrative examples of studies regarding hydrogel-clay nanocomposites are detailed in order to underline the progressive researches on hydrogel-clay-drug pharmaceutical formulations able to respond to a series of demands for the most diverse applications. Brief descriptions of the different techniques used for the characterization of the obtained complex hybrid materials such as: swelling, TGA, DSC, FTIR, XRD, mechanical, SEM, TEM and biology tests, are also included. Enlightened by the presented data, we can suppose that hydrogel-clay nanocomposites will still be a challenging subject of global assiduous researches. We can dare to dream to an efficient drug delivery platform for the treatment of multiple affection concomitantly, these being undoubtedly like "a tree of life" bearing different kinds of fruits and leaves proper for human healing.
引用
收藏
页码:919 / 954
页数:36
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