Diversity-oriented approach to linearly fused spirocycles via strategic utilization of a [2+2+2] cycloaddition and the Diels-Alder reaction

被引：15

作者：

Kotha, Sambasivarao ^{[1
]}

Ali, Rashid ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India

来源：

TETRAHEDRON | 2015年 / 71卷 / 10期

关键词：

Active methylene compounds; 2+2+2] Cycloaddition; Diels-Alder reaction; Spirocycles; Sultine derivatives; Wilkinson's catalyst; ORGANIC-SYNTHESIS; SYNTHETIC STRATEGY; KEY STEPS; DERIVATIVES; METATHESIS; ALKYNES; SPIRO; CYCLOTRIMERIZATION; (+/-)-STRYCHNINE; COCYCLIZATION;

D O I：

10.1016/j.tet.2015.01.009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have demonstrated a simple and an efficient protocol for assembling a library of linearly fused spirocycles in a diversity-oriented manner by utilizing two sequential atom-economic reactions such as a [2+2+2] cycloaddition and the Diels-Alder (DA) reaction. Herein, we have used rongalite for the formation of sultine derivatives, which are useful latent diene equivalents suitable for the DA sequence to generate a library of polycycles under mild reaction conditions. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：1597 / 1603

页数：7

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