Diversity-oriented approach to linearly fused spirocycles via strategic utilization of a [2+2+2] cycloaddition and the Diels-Alder reaction

被引：15
作者：
Kotha, Sambasivarao [1 ]
Ali, Rashid [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India
来源：
TETRAHEDRON | 2015年 / 71卷 / 10期
关键词：
Active methylene compounds; 2+2+2] Cycloaddition; Diels-Alder reaction; Spirocycles; Sultine derivatives; Wilkinson's catalyst; ORGANIC-SYNTHESIS; SYNTHETIC STRATEGY; KEY STEPS; DERIVATIVES; METATHESIS; ALKYNES; SPIRO; CYCLOTRIMERIZATION; (+/-)-STRYCHNINE; COCYCLIZATION;
D O I：
10.1016/j.tet.2015.01.009
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have demonstrated a simple and an efficient protocol for assembling a library of linearly fused spirocycles in a diversity-oriented manner by utilizing two sequential atom-economic reactions such as a [2+2+2] cycloaddition and the Diels-Alder (DA) reaction. Herein, we have used rongalite for the formation of sultine derivatives, which are useful latent diene equivalents suitable for the DA sequence to generate a library of polycycles under mild reaction conditions. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1597 / 1603
页数：7
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