Fluorescence Spectroscopy and imaging for noninvasive diagnostics: Applications to early cancer detection in the lung

被引：2

作者：

Mycek, MA ^{[1
]}

Urayama, P ^{[1
]}

Zhong, W ^{[1
]}

Sloboda, RD ^{[1
]}

机构：

[1] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

来源：

DIAGNOSTIC OPTICAL SPECTROSCOPY IN BIOMEDICINE II | 2003年 / 5141卷

关键词：

fluorescence diagnostics; fluorescence lifetime spectroscopy and imaging; neoplasia detection;

D O I：

10.1117/12.499867

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Tissue fluorescence spectroscopy and imaging, are being investigated as potential methods for non-invasive detection of pre-neoplastic change in the lung and other organ systems. A substantial contribution to tissue fluorescence is known to arise from endogenous cellular fluorophores. Using steady-state and time-resolved fluorescence spectroscopy and imaging, we characterized the endogenous fluorescence properties of immortalized and carcinogen transformed human bronchial epithelial cells. Non-invasive sensing of endogenous molecular biomarkers associated with human bronchial pre-neoplasia will be discussed.

引用

页码：70 / 80

页数：11

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