Antidepressant screening and flavonoids isolation from Eremostachys laciniata (L) Bunge

被引:0
作者
Nisar, Muhammad [1 ,2 ]
Khan, Salimullah [1 ,3 ]
Dar, Ahsana [4 ]
Rehman, Wajid [5 ]
Khan, Razaullah [6 ]
Jan, Irfanullah [7 ]
机构
[1] Univ Peshawar, Dept Pharm, Peshawar 25120, Pakistan
[2] Univ Peshawar, Inst Chem Sci, Peshawar 25120, Pakistan
[3] Abdul Wali Khan Univ, Dept Pharm, Mardan 23200, Pakistan
[4] Univ Karachi, HEJ Int Ctr Chem & Biol Studies, Karachi 75270, Pakistan
[5] Hazara Univ, Dept Chem, Mansehra 21300, Pakistan
[6] Massey Univ, Fertiliser & Lime Res Ctr, Palmerston North 11222, New Zealand
[7] Univ Peshawar, NCEG, Peshawar 25120, Pakistan
来源
AFRICAN JOURNAL OF BIOTECHNOLOGY | 2011年 / 10卷 / 09期
关键词
Eremostachys laciniata; antidepressant; apigenin; CORTICOTROPIN-RELEASING-FACTOR; DEPRESSION; LAMIACEAE; MICE;
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Eremostachys laciniata (L) Bunge (Lamiaceae), a rich source of flavonoids, has been investigated for chemical constituents and in vivo antidepressant property using forced swim test (FST) model. Five important compounds were isolated, including luteolin (1), apigenin (2), 5,8-dihydroxy-6,7-dimethoxyflavone (3), 5,7-dihydroxy-6,8-dimethoxyflavone (4) and luteolin 7-O-beta-glucoside (5). Compound 3 and 4 were isolated for the first time from the plant. A profound antidepressant action was observed for the crude extract at low doses, followed by a state of depression at higher doses. The initial antidepressant-like property of the plant may be attributed to the presence of apigenin like compounds; where as, an increase in immobility time observed at higher doses of the extract may be due to the sedative and calming effect of luteolin present in the plant. E. laciniata may be a potential source for the isolation of important natural products with antidepressant-like properties.
引用
收藏
页码:1696 / 1699
页数:4
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