Chiral Organocatalyzed Intermolecular Rauhut-Currier Reaction of Nitroalkenes with Ethyl Allenoate

被引：6
|
作者：
Takizawa, Shinobu [1 ]
Sako, Makoto [1 ]
Kishi, Kenta [1 ]
Shigenobu, Masashi [1 ]
Vo-Thanh, Giang [2 ]
Sasai, Hiroaki [1 ]
机构：
[1] Osaka Univ, ISIR, Ibaraki, Osaka 5670047, Japan
[2] Univ Paris Saclay, Univ Paris Sud, Lab Catalyse Mol, ICMMO,UMR8182, F-91405 Orsay, France
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2017年 / 65卷 / 11期
关键词：
Rauhut-Currier reaction; chiral organocatalysis; nitroalkene; alpha-functionalized allenoate; MORITA-BAYLIS-HILLMAN; ROUTE;
D O I：
10.1248/cpb.c17-00554
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An enantioselective intermolecular Rauhut-Currier (RC) reaction of nitroalkenes with ethyl allenoate has been established with quinidine-derived beta-isocupreidine. The present RC reaction afforded alpha-functionalized allenoates 3 in up to 94% yield with 59% enantiomeric excess (ee).
引用
收藏
页码：997 / 999
页数：3
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