Predictive factors of conservative breast surgery after neoadjuvant chemotherapy for breast cancer

Objectives. - The aim of our study was to evaluate the existence of predictive factors of conservative breast surgery after neoadjuvant chemotherapy (NAC) for breast cancer. Methods. - We included all women with invasive breast cancer who received NAC and underwent breast surgery between January 2007 and December 2013 in our institution. Univariable and multivariable analyses were performed to determine the association between clinical and histological factors and conservative breast surgery. Results. - During the study period, 229 women were included of whom 73 had breast.conservative surgery (32%). At univariable analysis, significant predictive factors were age (OR 0.97 [Cl 95% 0.95-0.99], P = 0.02), radiological size (OR 0.97 [CI 95% 0.96-0.99], P < 0.001), multifocality (OR 0.53 [CI 95% 0.271.05], P = 0.06), breast inflammation (OR 0.15 [CI 95% 0.07-0.32], P < 0.001) and the type of hormone receptors (P = 0.12). In multivariable analysis, all these factors but age were significant factors and thus considered as independent predictive factors. Conclusion. - This work permitted to identify independent predictive factors of breast conservative surgery after NAC for breast cancer that will be included in a risk scoring system that we aim to evaluate prospectively. (C) 2017 Elsevier Masson SAS. All rights reserved.