Genetically Determined Low-Density Lipoprotein Cholesterol and Risk of Subarachnoid Hemorrhage

被引：6

作者：

Acosta, Julian N. ^{[1
]}

Both, Cameron P. ^{[1
]}

Szejko, Natalia ^{[1
]}

Leasure, Audrey C. ^{[1
]}

Abdelhakim, Safa ^{[1
]}

Torres-Lopez, Victor M. ^{[1
]}

Brown, Stacy C. ^{[2
]}

Matouk, Charles C. ^{[3
]}

Gunel, Murat ^{[3
]}

Sheth, Kevin N. ^{[1
]}

Falcone, Guido J. ^{[1
]}

机构：

[1] Yale Sch Med, Dept Neurol, Div Neurocrit Care & Emergency Neurol, 15 York St,LLCI Room 1004D,POB 208018, New Haven, CT 06510 USA

[2] Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA

[3] Yale Sch Med, Dept Neurosurg, New Haven, CT 06510 USA

来源：

ANNALS OF NEUROLOGY | 2022年 / 91卷 / 01期

关键词：

INTRACEREBRAL HEMORRHAGE;

D O I：

10.1002/ana.26250

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We evaluated whether genetically elevated low-density lipoprotein cholesterol (LDL-C) levels are associated with lower risk of intracranial aneurysms and subarachnoid hemorrhage (IA/SAH). We conducted a 2-sample Mendelian randomization (MR) study. Our primary analysis used the inverse-variance weighted method. In secondary analyses, we implemented the MR-PRESSO method, restricted our analysis to LDL-C-specific instruments, and performed multivariate MR. A 1-mmol/l increase in genetically instrumented LDL-C levels was associated with a 17% lower risk of IA/SAH (odds ratio = 0.83, 95% confidence interval = 0.73-0.94, p = 0.004). Results remained consistent in secondary and multivariate analyses (all p < 0.05). Our results provide evidence for an inverse causal relationship between LDL-C levels and risk of IA/SAH. ANN NEUROL 2021

引用

页码：145 / 149

页数：5

共 20 条

[1] Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors [J].

Bakker, Mark K. ;

van der Spek, Rick A. A. ;

van Rheenen, Wouter ;

Morel, Sandrine ;

Bourcier, Romain ;

Hostettler, Isabel C. ;

Alg, Varinder S. ;

van Eijk, Kristel R. ;

Koido, Masaru ;

Akiyama, Masato ;

Terao, Chikashi ;

Matsuda, Koichi ;

Walters, Robin G. ;

Lin, Kuang ;

Li, Liming ;

Millwood, Iona Y. ;

Chen, Zhengming ;

Rouleau, Guy A. ;

Zhou, Sirui ;

Rannikmae, Kristiina ;

Sudlow, Cathie L. M. ;

Houlden, Henry ;

van den Berg, Leonard H. ;

Dina, Christian ;

Naggara, Olivier ;

Gentric, Jean-Christophe ;

Shotar, Eimad ;

Eugene, Francois ;

Desal, Hubert ;

Winsvold, Bendik S. ;

Borte, Sigrid ;

Johnsen, Marianne Bakke ;

Brumpton, Ben M. ;

Sandvei, Marie Softeland ;

Willer, Cristen J. ;

Hveem, Kristian ;

Zwart, John-Anker ;

Verschuren, W. M. Monique ;

Friedrich, Christoph M. ;

Hirsch, Sven ;

Schilling, Sabine ;

Dauvillier, Jerome ;

Martin, Olivier ;

Winsvold, Bendik S. ;

Borte, Sigrid ;

Johnsen, Marianne Bakke ;

Brumpton, Ben M. ;

Sandvei, Marie Softeland ;

Willer, Cristen J. .

NATURE GENETICS, 2020, 52 (12) :1303-1313

[2]

Broadbent Jim R, 2020, Wellcome Open Res, V5, P252, DOI 10.12688/wellcomeopenres.16374.1

[3] Lipid-Lowering Agents and High HDL (High-Density Lipoprotein) Are Inversely Associated With Intracranial Aneurysm Rupture [J].

Can, Anil ;

Castro, Victor M. ;

Dligach, Dmitriy ;

Finan, Sean ;

Yu, Sheng ;

Gainer, Vivian ;

Shadick, Nancy A. ;

Savova, Guergana ;

Murphy, Shawn ;

Cai, Tianxi ;

Weiss, Scott T. ;

Du, Rose .

STROKE, 2018, 49 (05) :1148-+

[4] Review of Cerebral Aneurysm Formation, Growth, and Rupture [J].

Chalouhi, Nohra ;

Hoh, Brian L. ;

Hasan, David .

STROKE, 2013, 44 (12) :3613-3622

[5]

Cheng Y, 2020, AM J TRANSL RES, V12, P463

[6] Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage [J].

Falcone, Guido J. ;

Kirsch, Elayna ;

Acosta, Julian N. ;

Noche, Rommell B. ;

Leasure, Audrey ;

Marini, Sandro ;

Chung, Jaeyoon ;

Selim, Magdy ;

Meschia, James F. ;

Brown, Devin L. ;

Worrall, Bradford B. ;

Tirschwell, David L. ;

Jagiella, Jeremiasz M. ;

Schmidt, Helena ;

Jimenez-Conde, Jordi ;

Fernandez-Cadenas, Israel ;

Lindgren, Arne ;

Slowik, Agnieszka ;

Gill, Dipender ;

Holmes, Michael ;

Phuah, Chia-Ling ;

Petersen, Nils H. ;

Matouk, Charles N. ;

Gunel, Murat ;

Sansing, Lauren ;

Bennett, Derrick ;

Chen, Zhengming ;

Sun, Luan L. ;

Clarke, Robert ;

Walters, Robin G. ;

Gill, Thomas M. ;

Biffi, Alessandro ;

Kathiresan, Sekar ;

Langefeld, Carl D. ;

Woo, Daniel ;

Rosand, Jonathan ;

Sheth, Kevin N. ;

Anderson, Christopher D. .

ANNALS OF NEUROLOGY, 2020, 88 (01) :56-66

[7]

Gatchev O, 1993, Ann Epidemiol, V3, P403, DOI 10.1016/1047-2797(93)90068-F

[8] Cerebral Intraparenchymal Hemorrhage A Review [J].

Gross, Bradley A. ;

Jankowitz, Brian T. ;

Friedlander, Robert M. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2019, 321 (13) :1295-1303

[9] A large electronic-health-record-based genome-wide study of serum lipids [J].

Hoffmann, Thomas J. ;

Theusch, Elizabeth ;

Haldar, Tanushree ;

Ranatunga, Dilrini K. ;

Jorgenson, Eric ;

Medina, Marisa W. ;

Kvale, Mark N. ;

Kwok, Pui-Yan ;

Schaefer, Catherine ;

Krauss, Ronald M. ;

Iribarren, Carlos ;

Risch, Neil .

NATURE GENETICS, 2018, 50 (03) :401-+

[10] Genetics of blood lipids among ∼300,000 multi-ethnic participants of the Million Veteran Program [J].

Klarin, Derek ;

Damrauer, Scott M. ;

Cho, Kelly ;

Sun, Yan, V ;

Teslovich, Tanya M. ;

Honerlaw, Jacqueline ;

Gagnon, David R. ;

Du Vall, Scott L. ;

Li, Jin ;

Peloso, Gina M. ;

Chaffin, Mark ;

Small, Aeron M. ;

Huang, Jie ;

Tang, Hua ;

Lynch, Julie A. ;

Ho, Yuk-Lam ;

Liu, Dajiangj ;

Emdin, Connor A. ;

Li, Alexander H. ;

Huffman, Jennifer E. ;

Lee, Jennifer S. ;

Natarajan, Pradeep ;

Chowdhury, Rajiv ;

Saleheen, Danish ;

Vujkovic, Ma Rijana ;

Baras, Aris ;

Pyarajan, Saiju ;

Di Angelantonio, Emanuele ;

Neale, Benjamin M. ;

Naheed, Al Iya ;

Khera, Amit, V ;

Danesh, John ;

Chan, Kyong-Mi ;

Abecasis, Goncalo ;

Willer, Cristen ;

Dewey, Frederick E. ;

Carey, David J. ;

Concato, John ;

Gaziano, J. Michael ;

O'Donnell, Christopherj ;

Tsao, Philip S. ;

Kathiresan, Sekar ;

Rader, Daniel J. ;

Wilson, Peter W. F. ;

Assimes, Themistocles L. .

NATURE GENETICS, 2018, 50 (11) :1514-+

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