Endotoxins and endocrine system

被引：11

作者：

Bertók, L ^{[1
]}

机构：

[1] Frederic Joliot Curie Natl Res Inst Radiobiol & R, H-1775 Budapest, Hungary

来源：

DOMESTIC ANIMAL ENDOCRINOLOGY | 1998年 / 15卷 / 05期

关键词：

D O I：

10.1016/S0739-7240(98)00032-0

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

There is good evidence for the interaction of neuroendocrine and immune systems. Endotoxin (LPS)-induced mediators (e.g., cytokines, prostaglandins etc) set on endocrine organs (e.g., the hypothalamo-pituitry-adrenal axis; thyroid glands etc). Endotoxin-treated, intestinal ischemic, or irradiated rats show decreased T(4) levels of blood. These animals cannot respond to TSH because the TSH-receptors of follicular membranes are disturbed by LPS in the thyroid glands. Radiodetoxified endotoxin is an effective immunstimulator and does not disturb the follicular membrane of thyroid gland. Thus, the T(4) production remains normal. The bile acids-as the end-product of cholesterol metabolism-play an important role in the physiological defense of macroorganisms against endotoxin and other lipid-like agents (Physico-chemical defense) and in the regulation of endocrine system, including the reproduction. (C) Elsevier Science Inc. 1998

引用

页码：305 / 308

页数：4

共 21 条

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