An Optimized System for Multiple Sequence Alignment

被引:2
作者
Yilmaz, Caglar [1 ]
Gok, Mustafa [2 ]
机构
[1] Cukurova Univ Balcali, Dept Comp Engn, TR-01330 Balcali, Turkey
[2] Cukurova Univ Balcali, Dept Elect & Elect Engn, TR-01330 Balcali, Turkey
来源
2009 INTERNATIONAL CONFERENCE ON RECONFIGURABLE COMPUTING AND FPGAS | 2009年
关键词
DESIGNS; CLUSTAL;
D O I
10.1109/ReConFig.2009.82
中图分类号
TP3 [计算技术、计算机技术];
学科分类号
0812 ;
摘要
Multiple sequence alignment (MSA) is one of the essential operations for identifying functional and structural relations among proteins. The execution of an MSA algorithm requires high-performance platforms. This paper presents a hardware system that speeds up the popular MSA software ClustalW. The proposed design performs the computation of the most time consuming step of the ClustalW. Test results show that the proposed hardware increases the performance of this step up to 85 times.
引用
收藏
页码:178 / +
页数:3
相关论文
共 11 条
[1]  
Dayhoff M O., 1978, Atlas of Protein Seq Struct, ppp 345
[2]  
Gok M, 2006, LECT NOTES COMPUT SC, V4263, P277
[3]  
Gok M, 2006, I C FIELD PROG LOGIC, P889
[4]   AMINO-ACID SUBSTITUTION MATRICES FROM PROTEIN BLOCKS [J].
HENIKOFF, S ;
HENIKOFF, JG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (22) :10915-10919
[5]   CLUSTAL - A PACKAGE FOR PERFORMING MULTIPLE SEQUENCE ALIGNMENT ON A MICROCOMPUTER [J].
HIGGINS, DG ;
SHARP, PM .
GENE, 1988, 73 (01) :237-244
[6]  
Lesk AM., 2005, INTRO BIOINFORMATICS, V2nd
[7]  
Lin X., 2005, P 8 INT C HIGH PERFO, P5
[8]  
Mount D.W., 2004, Bioinformatics: Sequence and Genome Analysis, Vsecond
[9]  
Oliver T, 2005, 11th International Conference on Parallel and Distributed Systems Workshops, Vol II, Proceedings,, P326
[10]   IDENTIFICATION OF COMMON MOLECULAR SUBSEQUENCES [J].
SMITH, TF ;
WATERMAN, MS .
JOURNAL OF MOLECULAR BIOLOGY, 1981, 147 (01) :195-197