CHARACTERIZATION OF SINGLE THYROID NODULES BY CONTRAST-ENHANCED 3-D ULTRASOUND

被引：75

作者：

Molinari, Filippo ^{[1
]}

Mantovani, Alice ^{[1
]}

Deandrea, Maurilio ^{[2
]}

Limone, Paolo ^{[2
]}

Garberoglio, Roberto ^{[3
]}

Suri, Jasjit S. ^{[4
,5
]}

机构：

[1] Politecn Torino, Dept Elect, Biolab, I-10129 Turin, Italy

[2] Umberto I Hosp, Endocrinol Sect, Turin, Italy

[3] Fdn Sci Mauriziana ONLUS, Turin, Italy

[4] Biomed Technol Inc, Denver, CO USA

[5] Idaho State Univ, Pocatello, ID 83209 USA

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 2010年 / 36卷 / 10期

关键词：

Contrast-enhanced ultrasound; Thyroid nodule; Skeleton; Vascular assessment; Tumor; POWER DOPPLER ULTRASOUND; THINNING ALGORITHM; MALIGNANCY; DIAGNOSIS; AGENTS;

D O I：

10.1016/j.ultrasmedbio.2010.07.011

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

High-resolution ultrasonography (HRUS) has potentialities in differential diagnosis between malignant and benign thyroid lesions, but interpretative pitfalls remain and accuracy is still poor. We developed an image processing technique for characterizing the intra-nodular vascularization of thyroid lesions. Twenty nodules (10 malignant) were analyzed by three-dimensional (3-D) contrast-enhanced ultrasound imaging. The 3-D volumes were preprocessed and skeletonized. Seven vascular parameters were computed on the skeletons: number of vascular trees (NT); vascular density (VD); number of branching nodes (or branching points) (NB); mean vessel radius (MR); 2-D (DM) and 3-D (SOAM) tortuosity; and inflection count metric (ICM). Results showed that the malignant nodules had higher values of NT (83.1 vs. 18.1), VD (00.4 vs. 0.01), NB (1453 vs. 552), DM (51 vs. 18), ICM (19.9 vs. 8.7) and SOAM (26 vs. 11). Quantification of nodular vascularization based on 3-D contrast-enhanced ultrasound and skeletonization could help differential diagnosis of thyroid lesions. (E-mail: filippo.molinari@polito.it) (C) 2010 World Federation for Ultrasound in Medicine & Biology.

引用

页码：1616 / 1625

页数：10

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