Novel thermoresponsive polymers having biodegradable phosphoester backbones

被引：101
作者：
Iwasaki, Yasuhiko
Wachiralarpphaithoon, Chookaet
Akiyoshi, Kazunari
机构：
[1] Kansai Univ, Fac Chem Mat & Bioengn, Dept Chem & Mat Engn, Suita, Osaka 5648680, Japan
[2] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan
[3] Tokyo Med & Dent Univ, Ctr Excellence Program Frontier Res Mol Destruct, Chiyoda Ku, Tokyo 1010062, Japan
来源：
MACROMOLECULES | 2007年 / 40卷 / 23期
关键词：
D O I：
10.1021/ma0715573
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Thermoresponsive polyphosphoesters have been synthesized by the simple copolymerization of two cyclic phosphoester monomers components. Poly(IPP-co-EP) was prepared by ring-opening polymerization using triisobutyl aluminum (iBu3Al) as an initiator. The polymerization was homogeneously conducted by a solvent-free reaction. It was observed that lower critical solution temperature (LCST) of poly(EP) (PEP) linearly increased with an increase in the composition of IPP. It was also reported that the LCST of thermoresponsive polymers can be controlled by compositions of hydrophobic and hydrophilic units. The thermoresponsivity of polyphosphoesters could also be observed under physiological temperatures, proving the applicability of these polymers in biomedical field.
引用
收藏
页码：8136 / 8138
页数：3
相关论文
共 39 条
[1]   Synthesis and characterization of block copolymer of polyphosphoester and poly(ε-caprolactone) [J].
Chen, DP ;
Wang, J .
MACROMOLECULES, 2006, 39 (02) :473-475
[2]   EFFECT OF COMONOMER HYDROPHILICITY AND IONIZATION ON THE LOWER CRITICAL SOLUTION TEMPERATURE OF N-ISOPROPYLACRYLAMIDE COPOLYMERS [J].
FEIL, H ;
BAE, YH ;
FEIJEN, J ;
KIM, SW .
MACROMOLECULES, 1993, 26 (10) :2496-2500
[3]  
Fujiwara T, 2001, MACROMOL BIOSCI, V1, P204, DOI 10.1002/1616-5195(20010701)1:5<204::AID-MABI204>3.3.CO
[4]  
2-8
[5]  
Guillet JEHM, 1968, J MACROMOL SCI CHEM, V2, P1441
[6]   Shell-cross-linked vesicles synthesized from block copolymers of poly(D,L-lactide) and poly (N-isopropyl acrylamide) as thermoresponsive nanocontainers [J].
Hales, M ;
Barner-Kowollik, C ;
Davis, TP ;
Stenzel, MH .
LANGMUIR, 2004, 20 (25) :10809-10817
[7]   Water-soluble and nonionic polyphosphoester: Synthesis, degradation, biocompatibility and enhancement of gene expression in mouse muscle [J].
Huang, SW ;
Wang, J ;
Zhang, PC ;
Mao, HQ ;
Zhuo, RX ;
Leong, KW .
BIOMACROMOLECULES, 2004, 5 (02) :306-311
[8]   Thermosensitivity of aqueous solutions of poly(N,N-diethylacrylamide) [J].
Idziak, I ;
Avoce, D ;
Lessard, D ;
Gravel, D ;
Zhu, XX .
MACROMOLECULES, 1999, 32 (04) :1260-1263
[9]   Novel biodegradable polyphosphate cross-linker for making biocompatible hydrogel [J].
Iwasaki, Y ;
Nakagawa, C ;
Ohtomi, M ;
Ishihara, K ;
Akiyoshi, K .
BIOMACROMOLECULES, 2004, 5 (03) :1110-1115
[10]   Design of biodegradable amphiphilic polymers: Well-defined amphiphilic polyphosphates with hydrophilic graft chains via ATRP [J].
Iwasaki, Y ;
Akiyoshi, K .
MACROMOLECULES, 2004, 37 (20) :7637-7642
1234