Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice

被引：57

作者：

Lin, Yan ^{[1
]}

Kuang, Yi ^{[1
]}

Li, Kai ^{[1
]}

Wang, Shuang ^{[1
]}

Ji, Shuai ^{[1
]}

Chen, Kuan ^{[1
]}

Song, Wei ^{[1
]}

Qiao, Xue ^{[1
]}

Ye, Min ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2017年 / 25卷 / 20期

基金：

中国国家自然科学基金;

关键词：

Glycyrrhiza inflata; Nrf2; activation; Hepatoprotective; CCl4-induced liver injury; Chalcones; BIOACTIVE CONSTITUENTS; PHENOLIC CONSTITUENTS; FLAVONOIDS; DERIVATIVES; CHALCONES; LICORICE; ISOFLAVONOIDS; ANTIOXIDANT; COMPONENTS; ROOT;

D O I：

10.1016/j.bmc.2017.08.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycyrrhiza inflata (licorice) has been used to treat liver diseases for a long history. However, the bioactive compounds are still not clear. In this work, 77 compounds, including 9 new ones, were isolated from the EtOAc extract of the roots and rhizomes of G. inflata. The Nrf2 activation activities of all compounds were screened using ARE-luciferase reporter assay on HepG2C8 cells. The results indicated a number of chalcones were potent Nrf2 activators, including 11 (licochalcone A, 4.07-fold), 12 (licochalcone B, 5.17-fold), and 19 (echinatin, 4.09-fold). Further studies indicated that 11, 12 and 19 remarkably attenuated CCl4-induced acute liver injury in mice (10 or 50 mg/kg, 7 days, ig.). These compounds could be promising hepatoprotective natural agents. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：5522 / 5530

页数：9

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