Determination of As by instrumental neutron activation analysis in sectioned hair samples for forensic purposes: chronic or acute poisoning?

Autopsy of 29-year old woman suspicious of committing suicide by the ingestion of As(2)O(3) yielded contradictory findings. All pathological findings as well as clinical symptoms suggested acute poisoning, while a highly elevated As level of 26.4 mu g g(-1) in her hair collected at the autopsy, which was determined with inductively coupled plasma mass spectrometry indicated chronic poisoning. To elucidate this discrepancy, instrumental neutron activation analysis (INAA) with proven accuracy was performed of another set of sectioned hair samples. Levels of As found by INAA in the range of 0.16-0.26 mu g g(-1) excluded chronic poisoning, because the person died after approximately 14 h after the As(2)O(3) ingestion. Two reasons for the discordant As results obtained by ICP-MS and INAA are considered: (1) accidental, non-removed contamination of hair on the As(2)O(3) ingestion; (2) erroneous performance of ICP-MS.