Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis

被引：30

作者：

Anderson, Emma L. ^{[1
,2
]}

Richmond, Rebecca C. ^{[1
,2
]}

Jones, Samuel E. ^{[3
]}

Hemani, Gibran ^{[1
,2
]}

Wade, Kaitlin H. ^{[1
,2
]}

Dashti, Hassan S. ^{[4
,5
]}

Lane, Jacqueline M. ^{[4
,5
,6
]}

Wang, Heming ^{[5
,7
]}

Saxena, Richa ^{[4
,5
,6
,7
]}

Brumpton, Ben ^{[1
,8
,9
]}

Korologou-Linden, Roxanna ^{[1
,2
]}

Nielsen, Jonas B. ^{[10
]}

Asvold, Bjorn Olav ^{[8
,11
]}

Abecasis, Goncalo ^{[10
]}

Coulthard, Elizabeth ^{[12
]}

Kyle, Simon D. ^{[13
]}

Beaumont, Robin N. ^{[3
]}

Tyrrell, Jessica ^{[3
]}

Frayling, Timothy M. ^{[3
]}

Munafo, Marcus R. ^{[1
,14
]}

Wood, Andrew R. ^{[3
]}

Ben-Shlomo, Yoav ^{[2
]}

Howe, Laura D. ^{[1
,2
]}

Lawlor, Deborah A. ^{[1
,2
]}

Weedon, Michael N. ^{[3
]}

Smith, George Davey ^{[1
,2
]}

机构：

[1] Univ Bristol, MRC Integrat Epidemiol Unit, Barley House, Bristol BS8 2BN, Avon, England

[2] Univ Bristol, Populat Hlth Sci, Med Sch, Bristol, Avon, England

[3] Univ Exeter, Med Sch, Genet Complex Traits, Exeter, Devon, England

[4] Harvard Med Sch, Ctr Genom Med, Massachusetts Gen Hosp, Boston, MA USA

[5] Broad Inst, Program Med & Populat Genet, Cambridge, MA USA

[6] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA USA

[7] Brigham & Womens Hosp, Harvard Med Sch, Div Sleep & Circadian Disorders, Boston, MA USA

[8] Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway

[9] Trondheim Reg & Univ Hosp, Dept Thorac Med, St Olavs Hosp, Trondheim, Norway

[10] Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI USA

[11] Trondheim Reg & Univ Hosp, Dept Endocrinol, St Olavs Hosp, Trondheim, Norway

[12] Univ Bristol, Med Sch, Translat Hlth Sci, Bristol, Avon, England

[13] Univ Oxford, Sleep & Circadian Neurosci Inst, Nuffield Dept Clin Neurosci, Oxford, England

[14] Univ Bristol, UK Ctr Tobacco & Alcohol Studies, Sch Psychol Sci, Bristol, Avon, England

来源：

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | 2021年 / 50卷 / 03期

基金：

英国惠康基金; 英国经济与社会研究理事会; 英国医学研究理事会; 欧洲研究理事会; 美国国家卫生研究院;

关键词：

Sleep; Alzheimer's disease; dementia; Mendelian randomization; causal inference; MILD COGNITIVE IMPAIRMENT; INCIDENT DEMENTIA; BIAS; INSTRUMENTS; ACCELEROMETER; ASSOCIATION; DURATION; LOCI;

D O I：

10.1093/ije/dyaa183

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: It is established that Alzheimer's disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset of AD. Methods: We used the largest published genome-wide association studies of self-reported and accelerometer-measured sleep traits (chronotype, duration, fragmentation, insomnia, daytime napping and daytime sleepiness), and AD. Mendelian randomization (MR) was used to estimate the causal effect of self-reported and accelerometer-measured sleep parameters on AD risk. Results: Overall, there was little evidence to support a causal effect of sleep traits on AD risk. There was some suggestive evidence that self-reported daytime napping was associated with lower AD risk [odds ratio (OR): 0.70, 95% confidence interval (CI): 0.50-0.99). Some other sleep traits (accelerometer-measured 'eveningness' and sleep duration, and self-reported daytime sleepiness) had ORs of a similar magnitude to daytime napping, but were less precisely estimated. Conclusions: Overall, we found very limited evidence to support a causal effect of sleep traits on AD risk. Our findings provide tentative evidence that daytime napping may reduce AD risk. Given that this is the first MR study of multiple self-report and objective sleep traits on AD risk, findings should be replicated using independent samples when such data become available.

引用

页码：817 / 828

页数：12

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