LPS Induces HMGB1 Release from Hepatocytes Via Both TLR4 and Caspase-11/Gasdermin D(GSDMD) Signalings

被引：0
|
作者：
Li, Wenbo [1 ,2 ]
Billiar, Timothy R. [1 ]
Deng, Meihong [1 ]
Scott, Melanie J. [1 ]
Lu, Ben [3 ]
Loughran, Patricia [4 ]
机构：
[1] Univ Pittsburgh, Surg, Pittsburgh, PA 15260 USA
[2] 2nd Xiangya Hosp, Plast Surg, Changsha, Hunan, Peoples R China
[3] 3rd Xiangya Hosp, Hematol, Changsha, Hunan, Peoples R China
[4] Univ Pittsburgh, Ctr Biol Imaging, Pittsburgh, PA 15260 USA
来源：
HEPATOLOGY | 2018年 / 68卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
841
引用
收藏
页码：497A / 497A
页数：1
相关论文
共 31 条
  • [1] LPS Induces Active HMGB1 Release From Hepatocytes Into Exosomes Through the Coordinated Activities of TLR4 and Caspase-11/GSDMD Signaling
    Li, Wenbo
    Deng, Meihong
    Loughran, Patricia A.
    Yang, Muqing
    Lin, Minjie
    Yang, Chenxuan
    Gao, Wentao
    Jin, Shuqing
    Li, Shilai
    Cai, Jingjing
    Lu, Ben
    Billiar, Timothy R.
    Scott, Melanie J.
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [2] NRF2 TRANSCRIPTIONALLY REGULATE CASPASE-11 EXPRESSION TO ACTIVATE HMGB1 RELEASE BY HEPATOCYTES
    Khambu, Bilon
    Cai Genxiang
    Liu, Gang
    Bailey, Niani
    Ma, Michelle
    Chen, Xiaoyun
    Li, Yu
    Yin, Xiao-Ming
    HEPATOLOGY, 2021, 74 : 288A - 288A
  • [3] Caspase-11 regulates HMGB1 release from liver during polymicrobial sepsis
    Deng, Meihong
    Scott, Melanie
    Billiar, Timothy
    JOURNAL OF IMMUNOLOGY, 2015, 194
  • [4] HMGB1 is upregulated in ASM in asthma and induces ASM contraction via TLR4
    Di Candia, Leonarda
    Saunders, Ruth
    Challiss, John
    Brightling, Christopher
    EUROPEAN RESPIRATORY JOURNAL, 2015, 46
  • [5] NRF2 transcriptionally regulates Caspase-11 expression to activate HMGB1 release by Autophagy-deficient hepatocytes
    Bilon Khambu
    Genxiang Cai
    Gang Liu
    Niani Tiaye Bailey
    Arissa A. Mercer
    Kamal Baral
    Michelle Ma
    Xiaoyun Chen
    Yu Li
    Xiao-Ming Yin
    Cell Death Discovery, 9
  • [6] NRF2 transcriptionally regulates Caspase-11 expression to activate HMGB1 release by Autophagy-deficient hepatocytes
    Khambu, Bilon
    Cai, Genxiang
    Liu, Gang
    Bailey, Niani Tiaye
    Mercer, Arissa A. A.
    Baral, Kamal
    Ma, Michelle
    Chen, Xiaoyun
    Li, Yu
    Yin, Xiao-Ming
    CELL DEATH DISCOVERY, 2023, 9 (01)
  • [7] HMGB1 induces chondrocyte hypertrophy and matrix catabolism via TLR2 and TLR4 signaling in chondrocytes
    Bryan, Ru L.
    Terkeltaub, Robert
    ARTHRITIS AND RHEUMATISM, 2008, 58 (09): : S873 - S874
  • [8] SERUM AMYLOID A INDUCES HMGB1 RELEASE IN A TLR4/RAGE- AND PKR-DEPENDENT FASHION
    Li, W.
    Zhu, S.
    D'Amore, J.
    D'Angelo, J.
    Li, J.
    Yang, H.
    Wang, P.
    Tracey, K. J.
    Sama, A.
    Wang, H.
    SHOCK, 2015, 43 (06): : 57 - 58
  • [9] TLR4 activation induces IL-1β release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung
    Suffwan Eltom
    Maria G Belvisi
    Liang Yew-Booth
    Bilel Dekkak
    Sarah A Maher
    Eric D Dubuis
    Victoria Jones
    Kate A Fitzgerald
    Mark A Birrell
    Respiratory Research, 15
  • [10] TLR4 activation induces IL-1β release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung
    Eltom, Suffwan
    Belvisi, Maria G.
    Yew-Booth, Liang
    Dekkak, Bilel
    Maher, Sarah A.
    Dubuis, Eric D.
    Jones, Victoria
    Fitzgerald, Kate A.
    Birrell, Mark A.
    RESPIRATORY RESEARCH, 2014, 15
1234