Cebranopadol: a first in-class example of a nociceptin/orphanin FQ receptor and opioid receptor agonist

被引:41
|
作者
Lambert, D. G. [1 ]
Bird, M. F. [1 ]
Rowbotham, D. J. [1 ]
机构
[1] Univ Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Div Anaesthesia Crit Care & Pain Management, Leicester LE2 7LX, Leics, England
关键词
KNOCK-OUT MICE; MORPHINE-TOLERANCE; DRUG-ABUSE; DEPENDENCE; NOP; PEPTIDE; TARGET;
D O I
10.1093/bja/aeu332
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
引用
收藏
页码:364 / 366
页数:3
相关论文
共 50 条
  • [1] Cebranopadol: a first-in-class potent analgesic agent with agonistic activity at nociceptin/orphanin FQ and opioid receptors
    Salat, Kinga
    Jakubowska, Anna
    Kulig, Katarzyna
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2015, 24 (06) : 837 - 844
  • [2] Nociceptin/orphanin FQ receptor ligands and translational challenges: focus on cebranopadol as an innovative analgesic
    Calo, G.
    Lambert, D. G.
    BRITISH JOURNAL OF ANAESTHESIA, 2018, 121 (05) : 1105 - 1114
  • [3] Opioid-type Respiratory Depressant Side Effects of Cebranopadol in Rats Are Limited by Its Nociceptin/Orphanin FQ Peptide Receptor Agonist Activity
    Linz, Klaus
    Schroeder, Wolfgang
    Frosch, Stefanie
    Christoph, Thomas
    ANESTHESIOLOGY, 2017, 126 (04) : 708 - 715
  • [4] Pharmacogenomic study of the role of the nociceptin/orphanin FQ receptor and opioid receptors in diabetic hyperalgesia
    Rutten, Kris
    Tzschentke, Thomas M.
    Koch, Thomas
    Schiene, Klaus
    Christoph, Thomas
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 741 : 264 - 271
  • [5] Nociceptin/orphanin FQ receptor and pain: Feasibility of the fourth opioid family member
    Mannelli, Lorenzo Di Cesare
    Micheli, Laura
    Ghelardini, Carla
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2015, 766 : 151 - 154
  • [6] Synergistic interaction between the agonism of cebranopadol at nociceptin/orphanin FQ and classical opioid receptors in the rat spinal nerve ligation model
    Christoph, Thomas
    Raffa, Robert
    De Vry, Jean
    Schroeder, Wolfgang
    PHARMACOLOGY RESEARCH & PERSPECTIVES, 2018, 6 (06):
  • [7] UFP-112 a Potent and Long-Lasting Agonist Selective for the Nociceptin/Orphanin FQ Receptor
    Calo', Girolamo
    Rizzi, Anna
    Cifani, Carlo
    Di Bonaventura, Maria Vittoria Micioni
    Regoli, Domenico
    Massi, Maurizio
    Salvadori, Severo
    Lambert, David G.
    Guerrini, Remo
    CNS NEUROSCIENCE & THERAPEUTICS, 2011, 17 (03) : 178 - 198
  • [8] Synthesis, enantiomeric separation and docking studies of spiropiperidine analogues as ligands of the nociceptin/orphanin FQ receptor
    Battisti, Umberto M.
    Corrado, Sandra
    Sorbi, Claudia
    Cornia, Andrea
    Tait, Annalisa
    Malfacini, Davide
    Cerlesi, Maria Camilla
    Calo, Girolamo
    Brasili, Livio
    MEDCHEMCOMM, 2014, 5 (07) : 973 - 983
  • [9] [Dmt1]N/OFQ(1-13)-NH2: a potent nociceptin/orphanin FQ and opioid receptor universal agonist
    Molinari, S.
    Camarda, V.
    Rizzi, A.
    Marzola, G.
    Salvadori, S.
    Marzola, E.
    Molinari, P.
    McDonald, J.
    Ko, M. C.
    Lambert, D. G.
    Calo', G.
    Guerrini, R.
    BRITISH JOURNAL OF PHARMACOLOGY, 2013, 168 (01) : 151 - 162
  • [10] Pharmacological characterization of nociceptin/orphanin FQ receptors, a novel opioid receptor family, in the midbrain periaqueductal gray
    Chiou, LC
    Fan, SH
    Chuang, KC
    Liao, YY
    Lee, SZ
    CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY, 2004, 1025 : 398 - 403