Cannabinoid receptor CB1 mRNA is highly expressed in the rat ciliary body:: implications for the antiglaucoma properties of marihuana

被引：78
|
作者：
Porcella, A
Casellas, P
Gessa, GL
Pani, L
机构：
[1] CNR, Ctr Neuropharmacol, I-09124 Cagliari, Italy
[2] Univ Cagliari, Bb Brodie Dept Neurosci, I-09124 Cagliari, Italy
[3] Sanofi Rech, Dept Immunopharmacol, F-34082 Montpellier, France
来源：
MOLECULAR BRAIN RESEARCH | 1998年 / 58卷 / 1-2期
关键词：
glaucoma; THC; gene expression; RT-PCR; CB; eye;
D O I：
10.1016/S0169-328X(98)00105-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We used RT-PCR to measure relative differences in cannabinoid receptor (CB) mRNAs in the rat eye, comparing CB1 or CB2 transcripts to that of the normalizing reference gene beta(2) microglobulin (beta(2)m) significantly higher levels of CB1 mRNA levels were found in the ciliary body (0.84 +/- 0.05% of beta(2)m) than in the iris, (0.34 +/- 0.04% of beta(2)m), retina (0.07 +/- 0.005% of beta(2)m) and choroid (0.06 +/- 0.005% of beta(2)m) CB2 mRNA was undetectable. This expression pattern supports a specific role for the CB1 receptor in controlling intraocular pressure, helping to explain the antiglaucoma property of cannabinoids. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：240 / 245
页数：6
相关论文
共 12 条
  • [1] The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein
    Porcella, A
    Maxia, C
    Gessa, GL
    Pani, L
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (03) : 1123 - 1127
  • [2] Cannabinoid CB1 receptor is expressed in chromophobe renal cell carcinoma and renal oncocytoma
    Larrinaga, Gorka
    Sanz, Begona
    Blanco, Lorena
    Perez, Itxaro
    Candenas, Maria L.
    Pinto, Francisco M.
    Irazusta, Amaia
    Gil, Javier
    Lopez, Jose I.
    CLINICAL BIOCHEMISTRY, 2013, 46 (7-8) : 638 - 641
  • [3] Expression of cannabinoid CB1 receptor mRNA in basal ganglia of normal and parkinsonian human brain
    Hurley, MJ
    Mash, DC
    Jenner, P
    JOURNAL OF NEURAL TRANSMISSION, 2003, 110 (11) : 1279 - 1288
  • [4] CB1 cannabinoid receptor expression is regulated by glucose and feeding in rat pancreatic islets
    Vilches-Flores, Alonso
    Laura Delgado-Buenrostro, Norma
    Navarrete-Vazquez, Gabriel
    Villalobos-Molina, Rafael
    REGULATORY PEPTIDES, 2010, 163 (1-3) : 81 - 87
  • [5] Cannabinoid CB1 receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues
    Stamer, WD
    Golightly, SF
    Hosohata, Y
    Ryan, EP
    Porter, AC
    Varga, E
    Noecker, RJ
    Felder, CC
    Yamamura, HI
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 431 (03) : 277 - 286
  • [6] Epigenetic regulation of the cannabinoid receptor CB1 in an activity-based rat model of anorexia nervosa
    D'Addario, Claudio
    Zaplatic, Elizabeta
    Giunti, Elisa
    Pucci, Mariangela
    Micioni Di Bonaventura, Maria Vittoria
    Scherma, Maria
    Dainese, Enrico
    Maccarrone, Mauro
    Nilsson, Ida A.
    Cifani, Carlo
    Fadda, Paola
    INTERNATIONAL JOURNAL OF EATING DISORDERS, 2020, 53 (05) : 432 - 446
  • [7] Epigenetic regulation of the cannabinoid receptor CB1 in an activity-based rat model of anorexia nervosa (vol 53, pg 702, 2020)
    D'Addario, Claudio
    Zaplatic, Elizabeta
    Giunti, Elisa
    Pucci, Mariangela
    Micioni Di Bonaventura, Maria Vittoria
    Scherma, Maria
    Dainese, Enrico
    Maccarrone, Mauro
    Nilsson, Ida A.
    Cifani, Carlo
    Fadda, Paola
    INTERNATIONAL JOURNAL OF EATING DISORDERS, 2020, 53 (12) : 2095 - 2095
  • [8] Regulation of Hippocampal Cannabinoid CB1 Receptor Actions by Adenosine A1 Receptors and Chronic Caffeine Administration: Implications for the Effects of Δ9-Tetrahydrocannabinol on Spatial Memory
    Sousa, Vasco C.
    Assaife-Lopes, Natalia
    Ribeiro, Joaquim A.
    Pratt, Judith A.
    Brett, Ros R.
    Sebastiao, Ana M.
    NEUROPSYCHOPHARMACOLOGY, 2011, 36 (02) : 472 - 487
  • [9] Regulation of Hippocampal Cannabinoid CB1 Receptor Actions by Adenosine A1 Receptors and Chronic Caffeine Administration: Implications for the Effects of Δ9-Tetrahydrocannabinol on Spatial Memory
    Vasco C Sousa
    Natália Assaife-Lopes
    Joaquim A Ribeiro
    Judith A Pratt
    Ros R Brett
    Ana M Sebastião
    Neuropsychopharmacology, 2011, 36 : 472 - 487
  • [10] Direct and indirect interactions between cannabinoid CB1 receptor and group II metabotropic glutamate receptor signalling in layer V pyramidal neurons from the rat prefrontal cortex
    Barbara, JG
    Auclair, N
    Roisin, MP
    Otani, S
    Valjent, E
    Caboche, J
    Soubrie, P
    Crepel, F
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 17 (05) : 981 - 990
12