Cannabinoid receptor CB1 mRNA is highly expressed in the rat ciliary body:: implications for the antiglaucoma properties of marihuana

被引：79
作者：
Porcella, A
Casellas, P
Gessa, GL
Pani, L
机构：
[1] CNR, Ctr Neuropharmacol, I-09124 Cagliari, Italy
[2] Univ Cagliari, Bb Brodie Dept Neurosci, I-09124 Cagliari, Italy
[3] Sanofi Rech, Dept Immunopharmacol, F-34082 Montpellier, France
来源：
MOLECULAR BRAIN RESEARCH | 1998年 / 58卷 / 1-2期
关键词：
glaucoma; THC; gene expression; RT-PCR; CB; eye;
D O I：
10.1016/S0169-328X(98)00105-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We used RT-PCR to measure relative differences in cannabinoid receptor (CB) mRNAs in the rat eye, comparing CB1 or CB2 transcripts to that of the normalizing reference gene beta(2) microglobulin (beta(2)m) significantly higher levels of CB1 mRNA levels were found in the ciliary body (0.84 +/- 0.05% of beta(2)m) than in the iris, (0.34 +/- 0.04% of beta(2)m), retina (0.07 +/- 0.005% of beta(2)m) and choroid (0.06 +/- 0.005% of beta(2)m) CB2 mRNA was undetectable. This expression pattern supports a specific role for the CB1 receptor in controlling intraocular pressure, helping to explain the antiglaucoma property of cannabinoids. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：240 / 245
页数：6
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